BRD-K16189898_CHIR-99021_SKBR3_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K16189898_CHIR-99021_SKBR3_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRA3 adhesion G protein-coupled receptor A3
AEBP1 AE binding protein 1
AMD1 adenosylmethionine decarboxylase 1
CALR calreticulin
CELF2 CUGBP, Elav-like family member 2
COBL cordon-bleu WH2 repeat protein
COL18A1 collagen, type XVIII, alpha 1
COLEC12 collectin sub-family member 12
CRY1 cryptochrome circadian clock 1
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
EDNRB endothelin receptor type B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
GNAS GNAS complex locus
HIC2 hypermethylated in cancer 2
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
KIF5B kinesin family member 5B
KLF10 Kruppel-like factor 10
LEF1 lymphoid enhancer-binding factor 1
MLF1 myeloid leukemia factor 1
MXRA5 matrix-remodelling associated 5
NLGN4X neuroligin 4, X-linked
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PLAC8 placenta-specific 8
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPON1 spondin 1, extracellular matrix protein
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)
ZNF468 zinc finger protein 468

decreased expression

Symbol Name
ALOX5 arachidonate 5-lipoxygenase
APOE apolipoprotein E
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCNB2 cyclin B2
CD58 CD58 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CST7 cystatin F (leukocystatin)
CSTA cystatin A (stefin A)
DENND2D DENN/MADD domain containing 2D
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLS glutaminase
GPI glucose-6-phosphate isomerase
GRB7 growth factor receptor-bound protein 7
GSTM3 glutathione S-transferase mu 3 (brain)
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
JAG1 jagged 1
KANK1 KN motif and ankyrin repeat domains 1
KRT17 keratin 17, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAT2B methionine adenosyltransferase II, beta
MMD monocyte to macrophage differentiation-associated
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPN3 opsin 3
PEG10 paternally expressed 10
REEP5 receptor accessory protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
STAR steroidogenic acute regulatory protein
TANK TRAF family member-associated NFKB activator
TBC1D31 TBC1 domain family, member 31
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB38 zinc finger and BTB domain containing 38