BRD-K16189898_CHIR-99021_SKBR3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

198 genes differentially expressed following the BRD-K16189898_CHIR-99021_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
ADGRA3 adhesion G protein-coupled receptor A3
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BHLHE40 basic helix-loop-helix family, member e40
CANX calnexin
CCL20 chemokine (C-C motif) ligand 20
CDC27 cell division cycle 27
CFB complement factor B
CTBP1 C-terminal binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DHCR7 7-dehydrocholesterol reductase
DKC1 dyskeratosis congenita 1, dyskerin
DNASE1L3 deoxyribonuclease I-like 3
EMP3 epithelial membrane protein 3
EMX2 empty spiracles homeobox 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
HIST1H2BK histone cluster 1, H2bk
IL1R2 interleukin 1 receptor, type II
IL32 interleukin 32
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LARP1 La ribonucleoprotein domain family, member 1
LOC100505650 uncharacterized LOC100505650
LRPPRC leucine-rich pentatricopeptide repeat containing
LTF lactotransferrin
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MLXIP MLX interacting protein
NMU neuromedin U
NOLC1 nucleolar and coiled-body phosphoprotein 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
RAB2A RAB2A, member RAS oncogene family
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCP1 t-complex 1
TMX2 thioredoxin-related transmembrane protein 2
TUBB4B tubulin, beta 4B class IVb
TYRP1 tyrosinase-related protein 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AHR aryl hydrocarbon receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BCAS1 breast carcinoma amplified sequence 1
BCL6 B-cell CLL/lymphoma 6
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCNB2 cyclin B2
CCNG2 cyclin G2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CHRDL1 chordin-like 1
CKAP4 cytoskeleton-associated protein 4
CLDN4 claudin 4
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
CPM carboxypeptidase M
CRELD2 cysteine-rich with EGF-like domains 2
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD3 FXYD domain containing ion transport regulator 3
FZD2 frizzled class receptor 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX2 glutathione peroxidase 2
GRB7 growth factor receptor-bound protein 7
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HBP1 HMG-box transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA10 homeobox A10
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBB inhibin, beta B
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KRCC1 lysine-rich coiled-coil 1
LACTB2 lactamase, beta 2
LGALS8 lectin, galactoside-binding, soluble, 8
LPAR1 lysophosphatidic acid receptor 1
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFH neurofilament, heavy polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OBSL1 obscurin-like 1
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZD2 PDZ domain containing 2
PEG10 paternally expressed 10
PGAP3 post-GPI attachment to proteins 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTCH1 patched 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PYGL phosphorylase, glycogen, liver
RAB31 RAB31, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A10 S100 calcium binding protein A10
S100A14 S100 calcium binding protein A14
S100A6 S100 calcium binding protein A6
S100P S100 calcium binding protein P
SATB1 SATB homeobox 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFRP4 secreted frizzled-related protein 4
SPDEF SAM pointed domain containing ETS transcription factor
STON1 stonin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TCAF1 TRPM8 channel-associated factor 1
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
TMEM50A transmembrane protein 50A
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSPAN31 tetraspanin 31
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WEE1 WEE1 G2 checkpoint kinase