BRD-K16189898_CHIR-99021_PC3_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K16189898_CHIR-99021_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALB albumin
ANKRD10 ankyrin repeat domain 10
ANXA4 annexin A4
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
BMP4 bone morphogenetic protein 4
BSG basigin (Ok blood group)
BST2 bone marrow stromal cell antigen 2
CAST calpastatin
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DAPK1 death-associated protein kinase 1
ECHDC2 enoyl CoA hydratase domain containing 2
EMP3 epithelial membrane protein 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FAT1 FAT atypical cadherin 1
FXYD2 FXYD domain containing ion transport regulator 2
GPR183 G protein-coupled receptor 183
GRB10 growth factor receptor-bound protein 10
IGKV1-5 immunoglobulin kappa variable 1-5
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LUC7L3 LUC7-like 3 (S. cerevisiae)
MXRA5 matrix-remodelling associated 5
PFKL phosphofructokinase, liver
PHGDH phosphoglycerate dehydrogenase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
S100A2 S100 calcium binding protein A2
SDC2 syndecan 2
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSBP2 single-stranded DNA binding protein 2
SSR4 signal sequence receptor, delta
TRBC1 T cell receptor beta constant 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
WBP5 WW domain binding protein 5
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALOX15B arachidonate 15-lipoxygenase, type B
ANXA3 annexin A3
APOD apolipoprotein D
BCL6 B-cell CLL/lymphoma 6
BOP1 block of proliferation 1
CCNA1 cyclin A1
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLDN3 claudin 3
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP4 dual specificity phosphatase 4
EMP2 epithelial membrane protein 2
FAM107A family with sequence similarity 107, member A
FBLN5 fibulin 5
FOXG1 forkhead box G1
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GYG1 glycogenin 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MLPH melanophilin
MSMB microseminoprotein, beta-
MUC2 mucin 2, oligomeric mucus/gel-forming
OXTR oxytocin receptor
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PIP prolactin-induced protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SRI sorcin
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGM4 transglutaminase 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM47 transmembrane protein 47
TPM1 tropomyosin 1 (alpha)
TTC39A tetratricopeptide repeat domain 39A
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WNT5A wingless-type MMTV integration site family, member 5A