BRD-K16189898_CHIR-99021_MDAMB231_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K16189898_CHIR-99021_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BHLHE40 basic helix-loop-helix family, member e40
CA2 carbonic anhydrase II
CHMP6 charged multivesicular body protein 6
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DPT dermatopontin
EDNRB endothelin receptor type B
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GPC4 glypican 4
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
IER3 immediate early response 3
KCTD12 potassium channel tetramerization domain containing 12
LAMP3 lysosomal-associated membrane protein 3
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
NQO1 NAD(P)H dehydrogenase, quinone 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMP22 peripheral myelin protein 22
RFC5 replication factor C (activator 1) 5, 36.5kDa
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINT1 serine peptidase inhibitor, Kunitz type 1
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBA1A tubulin, alpha 1a
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
BEX1 brain expressed, X-linked 1
CAPRIN2 caprin family member 2
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHIC2 cysteine-rich hydrophobic domain 2
CLCA1 chloride channel accessory 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAS Fas cell surface death receptor
FLRT2 fibronectin leucine rich transmembrane protein 2
GSTA4 glutathione S-transferase alpha 4
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
JADE2 jade family PHD finger 2
KDM5D lysine (K)-specific demethylase 5D
KRAS Kirsten rat sarcoma viral oncogene homolog
KRCC1 lysine-rich coiled-coil 1
LAMB1 laminin, beta 1
LPIN1 lipin 1
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NDC80 NDC80 kinetochore complex component
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RGS4 regulator of G-protein signaling 4
RHOBTB3 Rho-related BTB domain containing 3
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TLR4 toll-like receptor 4
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9