BRD-K16189898_CHIR-99021_LNCAP_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K16189898_CHIR-99021_LNCAP_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CA2 carbonic anhydrase II
CDC42 cell division cycle 42
CLU clusterin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOK5 docking protein 5
EMX2 empty spiracles homeobox 2
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HBD hemoglobin, delta
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IL17RB interleukin 17 receptor B
MAP7 microtubule-associated protein 7
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
RPL10 ribosomal protein L10
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STAG3 stromal antigen 3
STC2 stanniocalcin 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TMEM2 transmembrane protein 2
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACPP acid phosphatase, prostate
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ANXA6 annexin A6
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BPHL biphenyl hydrolase-like (serine hydrolase)
C7 complement component 7
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD14 CD14 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLEC11A C-type lectin domain family 11, member A
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CTSZ cathepsin Z
CXCL3 chemokine (C-X-C motif) ligand 3
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
E2F2 E2F transcription factor 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV1 ets variant 1
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXA1 forkhead box A1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
G0S2 G0/G1 switch 2
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JCHAIN joining chain of multimeric IgA and IgM
KDM5D lysine (K)-specific demethylase 5D
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MLPH melanophilin
MMP10 matrix metallopeptidase 10
MX2 MX dynamin-like GTPase 2
MYO6 myosin VI
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PPAP2A phosphatidic acid phosphatase type 2A
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STON1 stonin 1
TAGLN transgelin
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN4 tetraspanin 4
TWIST1 twist family bHLH transcription factor 1
VCAN versican