BRD-K16189898_CHIR-99021_HT29_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K16189898_CHIR-99021_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
CCDC86 coiled-coil domain containing 86
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CD163 CD163 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DSP desmoplakin
EMP1 epithelial membrane protein 1
EREG epiregulin
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HIST1H2BK histone cluster 1, H2bk
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
LEF1 lymphoid enhancer-binding factor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MMP3 matrix metallopeptidase 3
NELL2 NEL-like 2 (chicken)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OLFML2B olfactomedin-like 2B
PDE4B phosphodiesterase 4B, cAMP-specific
PMP22 peripheral myelin protein 22
PRKCH protein kinase C, eta
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
RRAGD Ras-related GTP binding D
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
STX3 syntaxin 3
SYT1 synaptotagmin I
TRBC1 T cell receptor beta constant 1
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
AQP1 aquaporin 1 (Colton blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAS1 breast carcinoma amplified sequence 1
C1ORF106 chromosome 1 open reading frame 106
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP57 centrosomal protein 57kDa
COL4A2 collagen, type IV, alpha 2
CP ceruloplasmin (ferroxidase)
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
FBLN1 fibulin 1
FBP1 fructose-1,6-bisphosphatase 1
FCGBP Fc fragment of IgG binding protein
FOXO4 forkhead box O4
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GPC4 glypican 4
GPX2 glutathione peroxidase 2
HOOK2 hook microtubule-tethering protein 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KLHDC2 kelch domain containing 2
KRT20 keratin 20, type I
LITAF lipopolysaccharide-induced TNF factor
LOXL1 lysyl oxidase-like 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP10 low density lipoprotein receptor-related protein 10
LYZ lysozyme
MBNL2 muscleblind-like splicing regulator 2
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDNF neuron-derived neurotrophic factor
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPEPL1 aminopeptidase-like 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OXTR oxytocin receptor
PLAC8 placenta-specific 8
PLLP plasmolipin
PPARG peroxisome proliferator-activated receptor gamma
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC44A4 solute carrier family 44, member 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPINK1 serine peptidase inhibitor, Kazal type 1
TACSTD2 tumor-associated calcium signal transducer 2
TM4SF4 transmembrane 4 L six family member 4
TP53 tumor protein p53
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9
TXNIP thioredoxin interacting protein
WFDC1 WAP four-disulfide core domain 1
WFDC2 WAP four-disulfide core domain 2