BRD-K16189898_CHIR-99021_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K16189898_CHIR-99021_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CERS6 ceramide synthase 6
CLIC5 chloride intracellular channel 5
COL14A1 collagen, type XIV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CTSK cathepsin K
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
DUSP3 dual specificity phosphatase 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERAP2 endoplasmic reticulum aminopeptidase 2
ETV1 ets variant 1
ETV5 ets variant 5
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM134B family with sequence similarity 134, member B
FAM162A family with sequence similarity 162, member A
FBLN1 fibulin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR1 fibroblast growth factor receptor 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXC1 forkhead box C1
FZD1 frizzled class receptor 1
FZD7 frizzled class receptor 7
GEM GTP binding protein overexpressed in skeletal muscle
GPC4 glypican 4
GPI glucose-6-phosphate isomerase
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
HK2 hexokinase 2
HOXC10 homeobox C10
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
LAPTM4B lysosomal protein transmembrane 4 beta
LPAR1 lysophosphatidic acid receptor 1
METTL7A methyltransferase like 7A
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGP matrix Gla protein
MOXD1 monooxygenase, DBH-like 1
NFIB nuclear factor I/B
OSMR oncostatin M receptor
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH9 protocadherin 9
PCOLCE procollagen C-endopeptidase enhancer
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRR7 proline rich 7 (synaptic)
PTN pleiotrophin
QPRT quinolinate phosphoribosyltransferase
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLIT2 slit homolog 2 (Drosophila)
SOSTDC1 sclerostin domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG4 sperm associated antigen 4
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPON1 spondin 1, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TGFB3 transforming growth factor, beta 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TNC tenascin C
TPBG trophoblast glycoprotein
TRIB2 tribbles pseudokinase 2
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
WWTR1 WW domain containing transcription regulator 1
ZBED2 zinc finger, BED-type containing 2
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CD3D CD3d molecule, delta (CD3-TCR complex)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH13 cadherin 13
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
CLDN7 claudin 7
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
CYBB cytochrome b-245, beta polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FADS3 fatty acid desaturase 3
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GIMAP4 GTPase, IMAP family member 4
GIMAP6 GTPase, IMAP family member 6
GLIPR1 GLI pathogenesis-related 1
GNLY granulysin
GREB1 growth regulation by estrogen in breast cancer 1
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IDO1 indoleamine 2,3-dioxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL32 interleukin 32
IL4R interleukin 4 receptor
KRT18 keratin 18, type I
LAPTM5 lysosomal protein transmembrane 5
LCK LCK proto-oncogene, Src family tyrosine kinase
MAMLD1 mastermind-like domain containing 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MT1E metallothionein 1E
NNMT nicotinamide N-methyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NRIP3 nuclear receptor interacting protein 3
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PDGFA platelet-derived growth factor alpha polypeptide
PDZD8 PDZ domain containing 8
PODXL podocalyxin-like
PON3 paraoxonase 3
QPCT glutaminyl-peptide cyclotransferase
REXO2 RNA exonuclease 2
RFTN1 raftlin, lipid raft linker 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SRGN serglycin
STAP2 signal transducing adaptor family member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TAGLN transgelin
TAL1 T-cell acute lymphocytic leukemia 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRBC1 T cell receptor beta constant 1
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VNN1 vanin 1
ZW10 zw10 kinetochore protein