BRD-K16189898_CHIR-99021_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K16189898_CHIR-99021_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCP1 CUB domain containing protein 1
CLIC5 chloride intracellular channel 5
COL4A5 collagen, type IV, alpha 5
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
EFNB2 ephrin-B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM3C family with sequence similarity 3, member C
FAS Fas cell surface death receptor
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FZD7 frizzled class receptor 7
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
HILPDA hypoxia inducible lipid droplet-associated
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
LAMP5 lysosomal-associated membrane protein family, member 5
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MEF2C myocyte enhancer factor 2C
MXRA5 matrix-remodelling associated 5
NEU1 sialidase 1 (lysosomal sialidase)
NOV nephroblastoma overexpressed
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PRKCQ protein kinase C, theta
PSPH phosphoserine phosphatase
PTPRO protein tyrosine phosphatase, receptor type, O
RBM47 RNA binding motif protein 47
RRAGD Ras-related GTP binding D
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
STX3 syntaxin 3
TDO2 tryptophan 2,3-dioxygenase
TGFB3 transforming growth factor, beta 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CD59 CD59 molecule, complement regulatory protein
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CYR61 cysteine-rich, angiogenic inducer, 61
DFNA5 deafness, autosomal dominant 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
FSTL1 follistatin-like 1
GADD45B growth arrest and DNA-damage-inducible, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB2 high mobility group box 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
KRT7 keratin 7, type II
MAOA monoamine oxidase A
MARCKS myristoylated alanine-rich protein kinase C substrate
NQO1 NAD(P)H dehydrogenase, quinone 1
NUSAP1 nucleolar and spindle associated protein 1
PEG3 paternally expressed 3
PFN2 profilin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RFTN1 raftlin, lipid raft linker 1
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SRGN serglycin
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TM4SF1 transmembrane 4 L six family member 1
UGDH UDP-glucose 6-dehydrogenase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1