BRD-K16189898_CHIR-99021_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K16189898_CHIR-99021_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
ARMCX6 armadillo repeat containing, X-linked 6
BMI1 BMI1 proto-oncogene, polycomb ring finger
C1R complement component 1, r subcomponent
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPVL carboxypeptidase, vitellogenic-like
CTSC cathepsin C
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
EDNRB endothelin receptor type B
ENO2 enolase 2 (gamma, neuronal)
ETV1 ets variant 1
FAM63A family with sequence similarity 63, member A
FRZB frizzled-related protein
FZD7 frizzled class receptor 7
HOXA5 homeobox A5
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
JUN jun proto-oncogene
KIF14 kinesin family member 14
KRT1 keratin 1, type II
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
PCDH9 protocadherin 9
PCOLCE procollagen C-endopeptidase enhancer
PLIN2 perilipin 2
PTN pleiotrophin
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLIT2 slit homolog 2 (Drosophila)
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TGFB3 transforming growth factor, beta 3
TMEM45A transmembrane protein 45A
TNC tenascin C
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
AMOTL2 angiomotin like 2
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ASRGL1 asparaginase like 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL2A1 BCL2-related protein A1
BST1 bone marrow stromal cell antigen 1
C1ORF115 chromosome 1 open reading frame 115
C5AR1 complement component 5a receptor 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH13 cadherin 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CXCL10 chemokine (C-X-C motif) ligand 10
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
FADS3 fatty acid desaturase 3
FAM171A1 family with sequence similarity 171, member A1
FGF2 fibroblast growth factor 2 (basic)
FILIP1L filamin A interacting protein 1-like
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GREB1 growth regulation by estrogen in breast cancer 1
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
HBEGF heparin-binding EGF-like growth factor
IDO1 indoleamine 2,3-dioxygenase 1
IL1B interleukin 1, beta
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LEFTY1 left-right determination factor 1
LOC100505650 uncharacterized LOC100505650
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MSLN mesothelin
MT1E metallothionein 1E
MT1M metallothionein 1M
MUC16 mucin 16, cell surface associated
NPDC1 neural proliferation, differentiation and control, 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OAT ornithine aminotransferase
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PROM1 prominin 1
RGCC regulator of cell cycle
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPP1 secreted phosphoprotein 1
SRGN serglycin
STAP2 signal transducing adaptor family member 2
STXBP6 syntaxin binding protein 6 (amisyn)
TAL1 T-cell acute lymphocytic leukemia 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
TRH thyrotropin-releasing hormone
TUBB6 tubulin, beta 6 class V
WT1 Wilms tumor 1