BRD-K16189898_CHIR-99021_HME1_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K16189898_CHIR-99021_HME1_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
C3 complement component 3
CA1 carbonic anhydrase I
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EREG epiregulin
FABP7 fatty acid binding protein 7, brain
FASTKD5 FAST kinase domains 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GATA3 GATA binding protein 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPC4 glypican 4
H1F0 H1 histone family, member 0
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEIS3P1 Meis homeobox 3 pseudogene 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MYO5C myosin VC
NME5 NME/NM23 family member 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PDZK1 PDZ domain containing 1
PLAUR plasminogen activator, urokinase receptor
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKCB protein kinase C, beta
PRKCH protein kinase C, eta
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGCC regulator of cell cycle
SAP18 Sin3A-associated protein, 18kDa
SELL selectin L
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SORBS2 sorbin and SH3 domain containing 2
SPON1 spondin 1, extracellular matrix protein
STAP2 signal transducing adaptor family member 2
TICAM1 toll-like receptor adaptor molecule 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADRB2 adrenoceptor beta 2, surface
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
AURKB aurora kinase B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAB39 calcium binding protein 39
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNF cyclin F
CDCA4 cell division cycle associated 4
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CPE carboxypeptidase E
CRIP1 cysteine-rich protein 1 (intestinal)
DPYSL3 dihydropyrimidinase-like 3
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF5 eukaryotic translation initiation factor 5
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FMOD fibromodulin
FZD7 frizzled class receptor 7
GCH1 GTP cyclohydrolase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
HOXB6 homeobox B6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KDM3A lysine (K)-specific demethylase 3A
KLHL9 kelch-like family member 9
KLK5 kallikrein-related peptidase 5
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MMP12 matrix metallopeptidase 12
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLN phospholamban
PRELP proline/arginine-rich end leucine-rich repeat protein
PROM1 prominin 1
PSRC1 proline/serine-rich coiled-coil 1
REEP1 receptor accessory protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SLC25A46 solute carrier family 25, member 46
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TGFBR3 transforming growth factor, beta receptor III
TNS3 tensin 3
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF423 zinc finger protein 423