BRD-K16189898_CHIR-99021_HME1_3_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K16189898_CHIR-99021_HME1_3_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
C6ORF62 chromosome 6 open reading frame 62
CD81 CD81 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
COL6A1 collagen, type VI, alpha 1
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSK cathepsin K
CXCL10 chemokine (C-X-C motif) ligand 10
CYFIP1 cytoplasmic FMR1 interacting protein 1
DUSP2 dual specificity phosphatase 2
EREG epiregulin
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
H3F3B H3 histone, family 3B (H3.3B)
HCAR3 hydroxycarboxylic acid receptor 3
IGFBP6 insulin-like growth factor binding protein 6
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LGALS8 lectin, galactoside-binding, soluble, 8
LPPR4 lipid phosphate phosphatase-related protein type 4
NLRP2 NLR family, pyrin domain containing 2
NRN1 neuritin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCOLCE procollagen C-endopeptidase enhancer
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRAME preferentially expressed antigen in melanoma
PSD3 pleckstrin and Sec7 domain containing 3
RGCC regulator of cell cycle
SCRG1 stimulator of chondrogenesis 1
SDC2 syndecan 2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFRC transferrin receptor
TPST2 tyrosylprotein sulfotransferase 2
TWIST1 twist family bHLH transcription factor 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA2 annexin A2
ANXA3 annexin A3
ANXA5 annexin A5
AQP3 aquaporin 3 (Gill blood group)
BEX1 brain expressed, X-linked 1
CAST calpastatin
CCND2 cyclin D2
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHIC2 cysteine-rich hydrophobic domain 2
COX7B cytochrome c oxidase subunit VIIb
CRISP3 cysteine-rich secretory protein 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GSTM3 glutathione S-transferase mu 3 (brain)
HAT1 histone acetyltransferase 1
HOMER2 homer scaffolding protein 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
KAT6B K(lysine) acetyltransferase 6B
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAP7 microtubule-associated protein 7
MGAM maltase-glucoamylase
MN1 meningioma (disrupted in balanced translocation) 1
MYH11 myosin, heavy chain 11, smooth muscle
NEFH neurofilament, heavy polypeptide
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PAX2 paired box 2
PDGFC platelet derived growth factor C
PDZK1IP1 PDZK1 interacting protein 1
PLAT plasminogen activator, tissue
RPA3 replication protein A3, 14kDa
RRAGD Ras-related GTP binding D
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SYT1 synaptotagmin I
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TUSC3 tumor suppressor candidate 3