BRD-K16189898_CHIR-99021_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K16189898_CHIR-99021_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACSS3 acyl-CoA synthetase short-chain family member 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
APOB apolipoprotein B
ARL4C ADP-ribosylation factor-like 4C
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CD36 CD36 molecule (thrombospondin receptor)
CFB complement factor B
CFI complement factor I
CHN1 chimerin 1
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CXADR coxsackie virus and adenovirus receptor
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPP4 dipeptidyl-peptidase 4
FGL1 fibrinogen-like 1
GATA3 GATA binding protein 3
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HP haptoglobin
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI30 interferon, gamma-inducible protein 30
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LINC00341 long intergenic non-protein coding RNA 341
LMNA lamin A/C
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRN3 leucine rich repeat neuronal 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MMP12 matrix metallopeptidase 12
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRDX2 peroxiredoxin 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RAD51C RAD51 paralog C
RBP4 retinol binding protein 4, plasma
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SDC2 syndecan 2
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SPP1 secreted phosphoprotein 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
TBX3 T-box 3
TFRC transferrin receptor
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSKU tsukushi, small leucine rich proteoglycan
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
APOD apolipoprotein D
AXL AXL receptor tyrosine kinase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCNE2 cyclin E2
CD59 CD59 molecule, complement regulatory protein
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOPX HOP homeobox
HOXB2 homeobox B2
HOXB7 homeobox B7
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA2 heat shock 70kDa protein 2
IDO1 indoleamine 2,3-dioxygenase 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
INHBA inhibin, beta A
LEFTY1 left-right determination factor 1
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGAM maltase-glucoamylase
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NKG7 natural killer cell granule protein 7
NT5E 5'-nucleotidase, ecto (CD73)
OXTR oxytocin receptor
P3H2 prolyl 3-hydroxylase 2
PLA1A phospholipase A1 member A
PLCB4 phospholipase C, beta 4
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PROM1 prominin 1
PRSS23 protease, serine, 23
PTCH1 patched 1
PTX3 pentraxin 3, long
RAI14 retinoic acid induced 14
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RGS4 regulator of G-protein signaling 4
S100A12 S100 calcium binding protein A12
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STMN1 stathmin 1
TFPI2 tissue factor pathway inhibitor 2
TRIM22 tripartite motif containing 22
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A