BRD-K16189898_CHIR-99021_HME1_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K16189898_CHIR-99021_HME1_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRL2 adhesion G protein-coupled receptor L2
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
C8ORF33 chromosome 8 open reading frame 33
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CHD7 chromodomain helicase DNA binding protein 7
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CHN1 chimerin 1
CLU clusterin
COASY CoA synthase
COL3A1 collagen, type III, alpha 1
CRY1 cryptochrome circadian clock 1
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DHDDS dehydrodolichyl diphosphate synthase
DPP4 dipeptidyl-peptidase 4
DPT dermatopontin
DSP desmoplakin
EFNB2 ephrin-B2
FAM162A family with sequence similarity 162, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FZD7 frizzled class receptor 7
GAL galanin/GMAP prepropeptide
GPC4 glypican 4
GRB10 growth factor receptor-bound protein 10
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOMER1 homer scaffolding protein 1
IER3 immediate early response 3
IGF2R insulin-like growth factor 2 receptor
JUN jun proto-oncogene
KIF1B kinesin family member 1B
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTF lactotransferrin
MACF1 microtubule-actin crosslinking factor 1
MMP12 matrix metallopeptidase 12
MTDH metadherin
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PCDH9 protocadherin 9
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PRDX2 peroxiredoxin 2
RBM25 RNA binding motif protein 25
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RORA RAR-related orphan receptor A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSL1D1 ribosomal L1 domain containing 1
RTN3 reticulon 3
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SIRT3 sirtuin 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
SST somatostatin
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TESC tescalcin
TFRC transferrin receptor
TGOLN2 trans-golgi network protein 2
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIK TRAF2 and NCK interacting kinase
TSKU tsukushi, small leucine rich proteoglycan
USP6NL USP6 N-terminal like
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADRB2 adrenoceptor beta 2, surface
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOD apolipoprotein D
AXL AXL receptor tyrosine kinase
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CD93 CD93 molecule
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH13 cadherin 13
CDK14 cyclin-dependent kinase 14
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1L dynamin 1-like
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPS8 epidermal growth factor receptor pathway substrate 8
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
FN1 fibronectin 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
IFI16 interferon, gamma-inducible protein 16
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP7 insulin-like growth factor binding protein 7
IL1B interleukin 1, beta
IL7R interleukin 7 receptor
INHBA inhibin, beta A
IRS1 insulin receptor substrate 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF2 Kruppel-like factor 2
KLHDC2 kelch domain containing 2
LDB2 LIM domain binding 2
LHFP lipoma HMGIC fusion partner
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MLH1 mutL homolog 1
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MOK MOK protein kinase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLK myosin light chain kinase
NDN necdin, melanoma antigen (MAGE) family member
NT5E 5'-nucleotidase, ecto (CD73)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
P3H2 prolyl 3-hydroxylase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PLAC8 placenta-specific 8
PPAP2A phosphatidic acid phosphatase type 2A
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRSS23 protease, serine, 23
PTK2B protein tyrosine kinase 2 beta
PTX3 pentraxin 3, long
PXDN peroxidasin
RAI14 retinoic acid induced 14
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFTN1 raftlin, lipid raft linker 1
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RPA3 replication protein A3, 14kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STMN1 stathmin 1
TEX10 testis expressed 10
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMSB15A thymosin beta 15a
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican
VEGFC vascular endothelial growth factor C
WNT5A wingless-type MMTV integration site family, member 5A
XYLT1 xylosyltransferase I