BRD-K16189898_CHIR-99021_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K16189898_CHIR-99021_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL10A1 collagen, type X, alpha 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
FAS Fas cell surface death receptor
FOSL1 FOS-like antigen 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
IFRD1 interferon-related developmental regulator 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NPM3 nucleophosmin/nucleoplasmin 3
ODC1 ornithine decarboxylase 1
PMP22 peripheral myelin protein 22
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRPF19 pre-mRNA processing factor 19
PRRC2C proline-rich coiled-coil 2C
PRSS8 protease, serine, 8
PSAT1 phosphoserine aminotransferase 1
RAD23B RAD23 homolog B (S. cerevisiae)
RHOBTB3 Rho-related BTB domain containing 3
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SRRM2 serine/arginine repetitive matrix 2
SYT1 synaptotagmin I
TARS threonyl-tRNA synthetase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNIK TRAF2 and NCK interacting kinase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZC3H15 zinc finger CCCH-type containing 15

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AOX1 aldehyde oxidase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C3 complement component 3
CCND2 cyclin D2
CCND3 cyclin D3
CCNG2 cyclin G2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFD complement factor D (adipsin)
CFH complement factor H
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CP ceruloplasmin (ferroxidase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
GYG2 glycogenin 2
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
INHBB inhibin, beta B
KLHDC2 kelch domain containing 2
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
LSP1 lymphocyte-specific protein 1
MAGEA3 melanoma antigen family A3
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NSG1 neuron specific gene family member 1
OPN3 opsin 3
PBX1 pre-B-cell leukemia homeobox 1
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PIP prolactin-induced protein
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PON3 paraoxonase 3
PRSS23 protease, serine, 23
RNASE4 ribonuclease, RNase A family, 4
RPL37A ribosomal protein L37a
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPDEF SAM pointed domain containing ETS transcription factor
STK10 serine/threonine kinase 10
STMN1 stathmin 1
TAGLN transgelin
TCF4 transcription factor 4
TF transferrin
TIMP2 TIMP metallopeptidase inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TMSB15A thymosin beta 15a
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
ZMIZ1 zinc finger, MIZ-type containing 1