BRD-K16189898_CHIR-99021_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K16189898_CHIR-99021_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AHCYL1 adenosylhomocysteinase-like 1
ALG8 ALG8, alpha-1,3-glucosyltransferase
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL20 chemokine (C-C motif) ligand 20
CCP110 centriolar coiled coil protein 110kDa
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COL6A1 collagen, type VI, alpha 1
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKC1 dyskeratosis congenita 1, dyskerin
DUSP22 dual specificity phosphatase 22
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERO1L ERO1-like (S. cerevisiae)
FAM162A family with sequence similarity 162, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GLA galactosidase, alpha
GMDS GDP-mannose 4,6-dehydratase
GPI glucose-6-phosphate isomerase
HK2 hexokinase 2
HOXB6 homeobox B6
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
INSIG1 insulin induced gene 1
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NOV nephroblastoma overexpressed
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PGK1 phosphoglycerate kinase 1
PID1 phosphotyrosine interaction domain containing 1
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
PSAT1 phosphoserine aminotransferase 1
QKI QKI, KH domain containing, RNA binding
RANBP1 RAN binding protein 1
RPIA ribose 5-phosphate isomerase A
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIT2 slit homolog 2 (Drosophila)
SOX9 SRY (sex determining region Y)-box 9
SRGN serglycin
STAR steroidogenic acute regulatory protein
STIP1 stress-induced phosphoprotein 1
TARS threonyl-tRNA synthetase
TFF3 trefoil factor 3 (intestinal)
TGOLN2 trans-golgi network protein 2
TMX1 thioredoxin-related transmembrane protein 1
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
UGDH UDP-glucose 6-dehydrogenase
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
C1ORF106 chromosome 1 open reading frame 106
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42 cell division cycle 42
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLTB clathrin, light chain B
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRP1 cysteine and glycine-rich protein 1
CTBP2 C-terminal binding protein 2
CTGF connective tissue growth factor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FXYD5 FXYD domain containing ion transport regulator 5
FZD2 frizzled class receptor 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRK5 G protein-coupled receptor kinase 5
HBP1 HMG-box transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
INPP5F inositol polyphosphate-5-phosphatase F
ISG15 ISG15 ubiquitin-like modifier
JUP junction plakoglobin
KIF1BP KIF1 binding protein
KLHDC2 kelch domain containing 2
LBH limb bud and heart development
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MGP matrix Gla protein
MYOF myoferlin
NBR1 neighbor of BRCA1 gene 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR2F6 nuclear receptor subfamily 2, group F, member 6
OPN3 opsin 3
OXTR oxytocin receptor
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PGLS 6-phosphogluconolactonase
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
POSTN periostin, osteoblast specific factor
PSCA prostate stem cell antigen
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RFX5 regulatory factor X, 5 (influences HLA class II expression)
S100A11 S100 calcium binding protein A11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
STMN1 stathmin 1
STON1 stonin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFPI2 tissue factor pathway inhibitor 2
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMSB15A thymosin beta 15a
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TUBA1A tubulin, alpha 1a
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL1 vestigial-like family member 1
XIST X inactive specific transcript (non-protein coding)
YBX3 Y box binding protein 3
YPEL5 yippee-like 5 (Drosophila)