BRD-K16189898_CHIR-99021_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

152 genes differentially expressed following the BRD-K16189898_CHIR-99021_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AREG amphiregulin
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
BMP4 bone morphogenetic protein 4
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CPE carboxypeptidase E
CXCL13 chemokine (C-X-C motif) ligand 13
EREG epiregulin
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GLUL glutamate-ammonia ligase
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MCOLN1 mucolipin 1
NELL2 NEL-like 2 (chicken)
PCDH9 protocadherin 9
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRT3 sirtuin 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UGDH UDP-glucose 6-dehydrogenase
VARS valyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
EAPP E2F-associated phosphoprotein
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERBB2 erb-b2 receptor tyrosine kinase 2
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GSN gelsolin
HBP1 HMG-box transcription factor 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUNB jun B proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KLF2 Kruppel-like factor 2
KRT7 keratin 7, type II
KYNU kynureninase
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANSC1 MANSC domain containing 1
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
MEGF9 multiple EGF-like-domains 9
MLPH melanophilin
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MVP major vault protein
NBR1 neighbor of BRCA1 gene 1
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PERP PERP, TP53 apoptosis effector
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRKD1 protein kinase D1
QPCT glutaminyl-peptide cyclotransferase
RAB11A RAB11A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAS related RAS viral (r-ras) oncogene homolog
S100A11 S100 calcium binding protein A11
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A4 solute carrier family 16, member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPTSSA serine palmitoyltransferase, small subunit A
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCL vinculin
VNN1 vanin 1
YPEL5 yippee-like 5 (Drosophila)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein