BRD-K16189898_CHIR-99021_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

224 genes differentially expressed following the BRD-K16189898_CHIR-99021_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BMP4 bone morphogenetic protein 4
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CAB39 calcium binding protein 39
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK4 dickkopf WNT signaling pathway inhibitor 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPP4 dipeptidyl-peptidase 4
EFNB2 ephrin-B2
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAS Fas cell surface death receptor
FAT1 FAT atypical cadherin 1
FGF9 fibroblast growth factor 9
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GAB2 GRB2-associated binding protein 2
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAG1 jagged 1
JUN jun proto-oncogene
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRPPRC leucine-rich pentatricopeptide repeat containing
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MXRA5 matrix-remodelling associated 5
MYO10 myosin X
ODC1 ornithine decarboxylase 1
PAX8 paired box 8
PCDH9 protocadherin 9
PCP4 Purkinje cell protein 4
PDLIM5 PDZ and LIM domain 5
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSD3 pleckstrin and Sec7 domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP1 retinol binding protein 1, cellular
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
RTCA RNA 3'-terminal phosphate cyclase
RUFY3 RUN and FYVE domain containing 3
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STMN2 stathmin 2
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM87A transmembrane protein 87A
TNPO1 transportin 1
TOMM34 translocase of outer mitochondrial membrane 34
TRD T cell receptor delta locus
TSC22D1 TSC22 domain family, member 1
VGLL4 vestigial-like family member 4
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ATP10B ATPase, class V, type 10B
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CD99 CD99 molecule
CDH19 cadherin 19, type 2
CDK2 cyclin-dependent kinase 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLDN10 claudin 10
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DCN decorin
DEPTOR DEP domain containing MTOR-interacting protein
DHFR dihydrofolate reductase
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
ETFB electron-transfer-flavoprotein, beta polypeptide
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBN1 fibrillin 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRK5 G protein-coupled receptor kinase 5
GSTA1 glutathione S-transferase alpha 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
IFI16 interferon, gamma-inducible protein 16
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INHBA inhibin, beta A
INPP5F inositol polyphosphate-5-phosphatase F
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD3 potassium channel tetramerization domain containing 3
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
KRT18 keratin 18, type I
LAMA4 laminin, alpha 4
LIMCH1 LIM and calponin homology domains 1
LOXL2 lysyl oxidase-like 2
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
METRN meteorin, glial cell differentiation regulator
MGLL monoglyceride lipase
MOK MOK protein kinase
MYLK myosin light chain kinase
NCAPD2 non-SMC condensin I complex, subunit D2
NEBL nebulette
NID1 nidogen 1
OXTR oxytocin receptor
PLAT plasminogen activator, tissue
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLLP plasmolipin
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS21 protease, serine, 21 (testisin)
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
PXDN peroxidasin
RDX radixin
RIN2 Ras and Rab interactor 2
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SAP30 Sin3A-associated protein, 30kDa
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMAD3 SMAD family member 3
SNX10 sorting nexin 10
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
STMN1 stathmin 1
SYNM synemin, intermediate filament protein
THBS2 thrombospondin 2
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIP6 thyroid hormone receptor interactor 6
VCAN versican
VNN1 vanin 1
XYLT1 xylosyltransferase I
ZMIZ1 zinc finger, MIZ-type containing 1