BRD-K16118047_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K16118047_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
ASPN asporin
BCHE butyrylcholinesterase
BGN biglycan
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CHN1 chimerin 1
CHN2 chimerin 2
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CTBP2 C-terminal binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA5 defensin, alpha 5, Paneth cell-specific
FAM129A family with sequence similarity 129, member A
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GYPC glycophorin C (Gerbich blood group)
HIST1H2BG histone cluster 1, H2bg
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IPO13 importin 13
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LPAR6 lysophosphatidic acid receptor 6
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MMP1 matrix metallopeptidase 1
PCDH17 protocadherin 17
PRR15L proline rich 15-like
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SOCS2 suppressor of cytokine signaling 2
STK10 serine/threonine kinase 10
THY1 Thy-1 cell surface antigen
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
VCAM1 vascular cell adhesion molecule 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACOT9 acyl-CoA thioesterase 9
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMD1 adenosylmethionine decarboxylase 1
AREG amphiregulin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CDC42 cell division cycle 42
CLU clusterin
COCH cochlin
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
ECI2 enoyl-CoA delta isomerase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
HGD homogentisate 1,2-dioxygenase
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
KDM5D lysine (K)-specific demethylase 5D
MAP7 microtubule-associated protein 7
MARCKSL1 MARCKS-like 1
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
PER2 period circadian clock 2
PTER phosphotriesterase related
RBP4 retinol binding protein 4, plasma
RHOB ras homolog family member B
SAT1 spermidine/spermine N1-acetyltransferase 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b