BRD-K15791587_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K15791587_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AK4 adenylate kinase 4
BASP1 brain abundant, membrane attached signal protein 1
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHMP4A charged multivesicular body protein 4A
CRIP1 cysteine-rich protein 1 (intestinal)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EXT1 exostosin glycosyltransferase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ITM2C integral membrane protein 2C
JUP junction plakoglobin
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGED2 melanoma antigen family D2
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NARFL nuclear prelamin A recognition factor-like
NPY1R neuropeptide Y receptor Y1
NRIP3 nuclear receptor interacting protein 3
OLFML3 olfactomedin-like 3
PAIP1 poly(A) binding protein interacting protein 1
PCDH17 protocadherin 17
PENK proenkephalin
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RALGDS ral guanine nucleotide dissociation stimulator
REEP1 receptor accessory protein 1
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPARCL1 SPARC-like 1 (hevin)
SQLE squalene epoxidase
TMEM100 transmembrane protein 100
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ANXA3 annexin A3
BACE2 beta-site APP-cleaving enzyme 2
CALD1 caldesmon 1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD27 CD27 molecule
COTL1 coactosin-like F-actin binding protein 1
CTGF connective tissue growth factor
CTPS1 CTP synthase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM198B family with sequence similarity 198, member B
FERMT2 fermitin family member 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MBNL2 muscleblind-like splicing regulator 2
NOP16 NOP16 nucleolar protein
PDLIM5 PDZ and LIM domain 5
PPIF peptidylprolyl isomerase F
RCAN1 regulator of calcineurin 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC2 syndecan 2
SERBP1 SERPINE1 mRNA binding protein 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
STK17A serine/threonine kinase 17a
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TPM1 tropomyosin 1 (alpha)
TRAC T cell receptor alpha constant
TUBB2A tubulin, beta 2A class IIa
WDR1 WD repeat domain 1