BRD-K15616905_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K15616905_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADGRG1 adhesion G protein-coupled receptor G1
AREG amphiregulin
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
COL4A5 collagen, type IV, alpha 5
CRELD2 cysteine-rich with EGF-like domains 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLG1 golgi glycoprotein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV1-40 immunoglobulin lambda variable 1-40
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL7A methyltransferase like 7A
MT1X metallothionein 1X
MT2A metallothionein 2A
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLS1 plastin 1
PRKCD protein kinase C, delta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SMAD3 SMAD family member 3
SPEN spen family transcriptional repressor
TFF1 trefoil factor 1
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
ZBTB38 zinc finger and BTB domain containing 38
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ADGRL2 adhesion G protein-coupled receptor L2
AHNAK2 AHNAK nucleoprotein 2
ARMCX2 armadillo repeat containing, X-linked 2
CCNE1 cyclin E1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CORO1A coronin, actin binding protein, 1A
DCN decorin
EML1 echinoderm microtubule associated protein like 1
FHL1 four and a half LIM domains 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FRZB frizzled-related protein
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GRIA2 glutamate receptor, ionotropic, AMPA 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IL1R1 interleukin 1 receptor, type I
KLK11 kallikrein-related peptidase 11
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
OPHN1 oligophrenin 1
PCGF3 polycomb group ring finger 3
PDGFC platelet derived growth factor C
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGIS prostaglandin I2 (prostacyclin) synthase
REEP1 receptor accessory protein 1
RTN2 reticulon 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TPPP3 tubulin polymerization-promoting protein family member 3
VIM vimentin
XIST X inactive specific transcript (non-protein coding)