BRD-K15592317_CP466722_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K15592317_CP466722_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADIRF adipogenesis regulatory factor
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAALC brain and acute leukemia, cytoplasmic
CD40 CD40 molecule, TNF receptor superfamily member 5
CD69 CD69 molecule
CHN1 chimerin 1
CLU clusterin
CRIP1 cysteine-rich protein 1 (intestinal)
CTSK cathepsin K
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGR1 early growth response 1
EGR3 early growth response 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
MMP9 matrix metallopeptidase 9
MSRA methionine sulfoxide reductase A
MTCL1 microtubule crosslinking factor 1
NNMT nicotinamide N-methyltransferase
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
PGC progastricsin (pepsinogen C)
PLBD1 phospholipase B domain containing 1
S100P S100 calcium binding protein P
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SPARCL1 SPARC-like 1 (hevin)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADCY1 adenylate cyclase 1 (brain)
AIM1 absent in melanoma 1
ASPH aspartate beta-hydroxylase
BEX1 brain expressed, X-linked 1
CCP110 centriolar coiled coil protein 110kDa
CDC25B cell division cycle 25B
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CRELD2 cysteine-rich with EGF-like domains 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
FXYD5 FXYD domain containing ion transport regulator 5
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAS GNAS complex locus
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMG20B high mobility group 20B
IFI44L interferon-induced protein 44-like
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
LRRC17 leucine rich repeat containing 17
PDGFC platelet derived growth factor C
PXDN peroxidasin
RGS10 regulator of G-protein signaling 10
RTN1 reticulon 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SRGN serglycin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
VAV3 vav 3 guanine nucleotide exchange factor