BRD-K15588452_R-96544 hydrochloride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-K15588452_R-96544 hydrochloride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AKR1C1 aldo-keto reductase family 1, member C1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
COL10A1 collagen, type X, alpha 1
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
HLA-E major histocompatibility complex, class I, E
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MSMO1 methylsterol monooxygenase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
APOD apolipoprotein D
CCL2 chemokine (C-C motif) ligand 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CHL1 cell adhesion molecule L1-like
COL6A2 collagen, type VI, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
DEFB4A defensin, beta 4A
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNM1L dynamin 1-like
ECI2 enoyl-CoA delta isomerase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM46C family with sequence similarity 46, member C
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HILPDA hypoxia inducible lipid droplet-associated
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RCAN1 regulator of calcineurin 1
RNF167 ring finger protein 167
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SSR1 signal sequence receptor, alpha
TM9SF3 transmembrane 9 superfamily member 3
TNC tenascin C