BRD-K15409150_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

138 genes differentially expressed following the BRD-K15409150_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPN asporin
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
CELF2 CUGBP, Elav-like family member 2
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INHBA inhibin, beta A
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCOLN1 mucolipin 1
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MSLN mesothelin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
MYO6 myosin VI
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PER1 period circadian clock 1
PER2 period circadian clock 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLXNC1 plexin C1
RAB21 RAB21, member RAS oncogene family
RND3 Rho family GTPase 3
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TUFT1 tuftelin 1
VCAN versican
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
ALOX5 arachidonate 5-lipoxygenase
CADM1 cell adhesion molecule 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG1 cyclin G1
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
DLK1 delta-like 1 homolog (Drosophila)
DMD dystrophin
DPYD dihydropyrimidine dehydrogenase
FAM46A family with sequence similarity 46, member A
FCGBP Fc fragment of IgG binding protein
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8B golgin A8 family, member B
HSPA8 heat shock 70kDa protein 8
IFITM1 interferon induced transmembrane protein 1
IPO13 importin 13
KIAA0753 KIAA0753
LAMA4 laminin, alpha 4
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MME membrane metallo-endopeptidase
MYBPC1 myosin binding protein C, slow type
MYOF myoferlin
NDRG3 NDRG family member 3
NID1 nidogen 1
NRN1 neuritin 1
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRM protein tyrosine phosphatase, receptor type, M
RGS2 regulator of G-protein signaling 2
TFPI2 tissue factor pathway inhibitor 2
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
WFDC2 WAP four-disulfide core domain 2