BRD-K15108141_gemcitabine_HCC515_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K15108141_gemcitabine_HCC515_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CA12 carbonic anhydrase XII
CCL5 chemokine (C-C motif) ligand 5
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLCA2 chloride channel accessory 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
FASTKD5 FAST kinase domains 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER2 immediate early response 2
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL32 interleukin 32
IRF8 interferon regulatory factor 8
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NR4A1 nuclear receptor subfamily 4, group A, member 1
NT5DC2 5'-nucleotidase domain containing 2
PLAGL1 pleiomorphic adenoma gene-like 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRF1 perforin 1 (pore forming protein)
RGS16 regulator of G-protein signaling 16
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
WEE1 WEE1 G2 checkpoint kinase
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACACB acetyl-CoA carboxylase beta
ADIRF adipogenesis regulatory factor
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FN1 fibronectin 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IFI6 interferon, alpha-inducible protein 6
IL1R1 interleukin 1 receptor, type I
ISG15 ISG15 ubiquitin-like modifier
LPL lipoprotein lipase
MMD monocyte to macrophage differentiation-associated
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MYL9 myosin, light chain 9, regulatory
PCDH9 protocadherin 9
PLK1 polo-like kinase 1
RDX radixin
RHOQ ras homolog family member Q
RPS27L ribosomal protein S27-like
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
TMEM47 transmembrane protein 47
TPBG trophoblast glycoprotein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1