BRD-K15108141_gemcitabine_A549_6.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K15108141_gemcitabine_A549_6.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD164 CD164 molecule, sialomucin
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CNN3 calponin 3, acidic
DUSP14 dual specificity phosphatase 14
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
GATA3 GATA binding protein 3
GPC4 glypican 4
GSTP1 glutathione S-transferase pi 1
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGL immunoglobulin lambda locus
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JCHAIN joining chain of multimeric IgA and IgM
KRT6A keratin 6A, type II
LPAR6 lysophosphatidic acid receptor 6
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
NEFL neurofilament, light polypeptide
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NXN nucleoredoxin
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SOCS1 suppressor of cytokine signaling 1
ST5 suppression of tumorigenicity 5
TLE4 transducin-like enhancer of split 4
TMEM123 transmembrane protein 123
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
TRIM22 tripartite motif containing 22
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
ALDOB aldolase B, fructose-bisphosphate
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BMP6 bone morphogenetic protein 6
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FOLR1 folate receptor 1 (adult)
FST follistatin
GPSM2 G-protein signaling modulator 2
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
MKI67 marker of proliferation Ki-67
MT1H metallothionein 1H
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
ODC1 ornithine decarboxylase 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSRC1 proline/serine-rich coiled-coil 1
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
UBE2C ubiquitin-conjugating enzyme E2C