BRD-K14844937_METHYL-6,7-DIMETHOXY-4-ETHYL-beta-CARBOLINE-3-CARBOXYLATE_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K14844937_METHYL-6,7-DIMETHOXY-4-ETHYL-beta-CARBOLINE-3-CARBOXYLATE_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ATM ATM serine/threonine kinase
C3 complement component 3
CD38 CD38 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
CHRDL1 chordin-like 1
COG7 component of oligomeric golgi complex 7
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL13RA2 interleukin 13 receptor, alpha 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LRMP lymphoid-restricted membrane protein
MED13L mediator complex subunit 13-like
MEF2C myocyte enhancer factor 2C
MYOF myoferlin
NPIPB3 nuclear pore complex interacting protein family, member B3
OSBPL10 oxysterol binding protein-like 10
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRUNE2 prune homolog 2 (Drosophila)
S100A8 S100 calcium binding protein A8
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TRIB2 tribbles pseudokinase 2
USP34 ubiquitin specific peptidase 34
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
CCL2 chemokine (C-C motif) ligand 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSP desmoplakin
DUSP22 dual specificity phosphatase 22
EPHB2 EPH receptor B2
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GMDS GDP-mannose 4,6-dehydratase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL17RB interleukin 17 receptor B
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK6 mitogen-activated protein kinase 6
MSMO1 methylsterol monooxygenase 1
PCOLCE procollagen C-endopeptidase enhancer
PTGES prostaglandin E synthase
RAB11A RAB11A, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SQLE squalene epoxidase
TFF3 trefoil factor 3 (intestinal)
TNC tenascin C
TSPAN8 tetraspanin 8
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1