BRD-K14711204_4-(4-hydroxy-2,6-dimethylheptan-4-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K14711204_4-(4-hydroxy-2,6-dimethylheptan-4-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ADIPOR2 adiponectin receptor 2
AIM1 absent in melanoma 1
ANKRD10 ankyrin repeat domain 10
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP3 dual specificity phosphatase 3
EBP emopamil binding protein (sterol isomerase)
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GLRX glutaredoxin (thioltransferase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MET MET proto-oncogene, receptor tyrosine kinase
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOBP sine oculis binding protein homolog (Drosophila)
SQLE squalene epoxidase
STX1A syntaxin 1A (brain)
TFF1 trefoil factor 1
TM7SF2 transmembrane 7 superfamily member 2
VCAN versican

decreased expression

Symbol Name
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
MFAP2 microfibrillar-associated protein 2
SRRM2 serine/arginine repetitive matrix 2
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1