BRD-K14711204_4-(4-hydroxy-2,6-dimethylheptan-4-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K14711204_4-(4-hydroxy-2,6-dimethylheptan-4-yl)-N,N-diphenyl-1H-1,2,3-triazole-1-carboxamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALB albumin
ARG2 arginase 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
DCHS1 dachsous cadherin-related 1
DIO1 deiodinase, iodothyronine, type I
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F11R F11 receptor
FABP6 fatty acid binding protein 6, ileal
FBN2 fibrillin 2
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GNLY granulysin
GPNMB glycoprotein (transmembrane) nmb
GPR87 G protein-coupled receptor 87
GYPC glycophorin C (Gerbich blood group)
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HOMER3 homer scaffolding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IRF6 interferon regulatory factor 6
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MGP matrix Gla protein
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP12 matrix metallopeptidase 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NARFL nuclear prelamin A recognition factor-like
NCAM1 neural cell adhesion molecule 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PEG3 paternally expressed 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLVAP plasmalemma vesicle associated protein
PTK2B protein tyrosine kinase 2 beta
RAB15 RAB15, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TLE4 transducin-like enhancer of split 4
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
ADI1 acireductone dioxygenase 1
AHR aryl hydrocarbon receptor
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BASP1 brain abundant, membrane attached signal protein 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CETN3 centrin, EF-hand protein, 3
CHMP5 charged multivesicular body protein 5
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLIC4 chloride intracellular channel 4
CLINT1 clathrin interactor 1
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLD dihydrolipoamide dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP10 dual specificity phosphatase 10
EBNA1BP2 EBNA1 binding protein 2
EDNRB endothelin receptor type B
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
ETV1 ets variant 1
FAM134B family with sequence similarity 134, member B
FASTKD5 FAST kinase domains 5
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMDS GDP-mannose 4,6-dehydratase
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRSF1 G-rich RNA sequence binding factor 1
GSPT2 G1 to S phase transition 2
HCCS holocytochrome c synthase
HEXIM1 hexamethylene bis-acetamide inducible 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSDL2 hydroxysteroid dehydrogenase like 2
HSPA1A heat shock 70kDa protein 1A
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL18 interleukin 18
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITGB5 integrin, beta 5
KIAA0368 KIAA0368
KIF2C kinesin family member 2C
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KYNU kynureninase
LACTB2 lactamase, beta 2
LAMB1 laminin, beta 1
LAMP2 lysosomal-associated membrane protein 2
LIMCH1 LIM and calponin homology domains 1
LIMS1 LIM and senescent cell antigen-like domains 1
LPAR1 lysophosphatidic acid receptor 1
LY75 lymphocyte antigen 75
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MORC4 MORC family CW-type zinc finger 4
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDZD8 PDZ domain containing 8
PHF20 PHD finger protein 20
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK2 polo-like kinase 2
PPA1 pyrophosphatase (inorganic) 1
PRDX1 peroxiredoxin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QDPR quinoid dihydropteridine reductase
RAB14 RAB14, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RBM12 RNA binding motif protein 12
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
RFK riboflavin kinase
RPL27A ribosomal protein L27a
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEH1L SEH1-like (S. cerevisiae)
SERBP1 SERPINE1 mRNA binding protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLK STE20-like kinase
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOAT1 sterol O-acyltransferase 1
SOX9 SRY (sex determining region Y)-box 9
SSFA2 sperm specific antigen 2
STOM stomatin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TNC tenascin C
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TSNAX translin-associated factor X
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
TXN thioredoxin
UBQLN2 ubiquilin 2
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
WBP5 WW domain binding protein 5
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZNF131 zinc finger protein 131
ZNF330 zinc finger protein 330