BRD-K14609189_3-(5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

30 genes differentially expressed following the BRD-K14609189_3-(5-{[3-(4-methoxy-2-methylphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)propanoic acid_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADIRF adipogenesis regulatory factor
CPE carboxypeptidase E
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
FN1 fibronectin 1
IPO13 importin 13
LRMP lymphoid-restricted membrane protein
MYRF myelin regulatory factor
PDE10A phosphodiesterase 10A
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS13 regulator of G-protein signaling 13
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
HOXB2 homeobox B2
IER3 immediate early response 3
IFI44L interferon-induced protein 44-like
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
KRT1 keratin 1, type II
LAPTM4B lysosomal protein transmembrane 4 beta
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
TNC tenascin C
UBE2S ubiquitin-conjugating enzyme E2S