BRD-K14109347_LY2603618_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K14109347_LY2603618_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DIRAS3 DIRAS family, GTP-binding RAS-like 3
EBP emopamil binding protein (sterol isomerase)
EGR1 early growth response 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
NTS neurotensin
P4HB prolyl 4-hydroxylase, beta polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPTBN1 spectrin, beta, non-erythrocytic 1
TARP TCR gamma alternate reading frame protein
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
AIM1 absent in melanoma 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CA2 carbonic anhydrase II
CD24 CD24 molecule
CD9 CD9 molecule
CLMN calmin (calponin-like, transmembrane)
COL5A1 collagen, type V, alpha 1
CTSK cathepsin K
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EMP1 epithelial membrane protein 1
FOXO3 forkhead box O3
FRZB frizzled-related protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT19 keratin 19, type I
LUM lumican
LYZ lysozyme
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PIP prolactin-induced protein
PMP22 peripheral myelin protein 22
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKCA protein kinase C, alpha
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SULF1 sulfatase 1
UBE2G1 ubiquitin-conjugating enzyme E2G 1