BRD-K14109347_LY2603618_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K14109347_LY2603618_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHCYL1 adenosylhomocysteinase-like 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CLEC2B C-type lectin domain family 2, member B
COPS7A COP9 signalosome subunit 7A
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUNB jun B proto-oncogene
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LGALS1 lectin, galactoside-binding, soluble, 1
LIMA1 LIM domain and actin binding 1
LRP10 low density lipoprotein receptor-related protein 10
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MVP major vault protein
MXRA7 matrix-remodelling associated 7
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSMR oncostatin M receptor
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDLIM4 PDZ and LIM domain 4
PEG3 paternally expressed 3
PGF placental growth factor
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PRNP prion protein
PROCR protein C receptor, endothelial
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RALB v-ral simian leukemia viral oncogene homolog B
RB1CC1 RB1-inducible coiled-coil 1
RGS16 regulator of G-protein signaling 16
RPS27L ribosomal protein S27-like
S100A6 S100 calcium binding protein A6
SCPEP1 serine carboxypeptidase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFXN3 sideroflexin 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC22A18 solute carrier family 22, member 18
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SRPX2 sushi-repeat containing protein, X-linked 2
STOM stomatin
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TRIM22 tripartite motif containing 22
TWF2 twinfilin actin binding protein 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AUTS2 autism susceptibility candidate 2
BAD BCL2-associated agonist of cell death
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F12 coagulation factor XII (Hageman factor)
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC3 glypican 3
GPR88 G protein-coupled receptor 88
GRB14 growth factor receptor-bound protein 14
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
IFI6 interferon, alpha-inducible protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIFC1 kinesin family member C1
LBR lamin B receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MKI67 marker of proliferation Ki-67
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUTF2 nuclear transport factor 2
PBK PDZ binding kinase
PDZK1 PDZ domain containing 1
PHGDH phosphoglycerate dehydrogenase
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRC1 protein regulator of cytokinesis 1
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPA1 replication protein A1, 70kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORBS3 sorbin and SH3 domain containing 3
SPEN spen family transcriptional repressor
STMN1 stathmin 1
TACC3 transforming, acidic coiled-coil containing protein 3
TFF3 trefoil factor 3 (intestinal)
TKT transketolase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
WHSC1 Wolf-Hirschhorn syndrome candidate 1