BRD-K14109347_LY2603618_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K14109347_LY2603618_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX15B arachidonate 15-lipoxygenase, type B
ARHGAP29 Rho GTPase activating protein 29
ARL4A ADP-ribosylation factor-like 4A
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
C3ORF14 chromosome 3 open reading frame 14
CCNL1 cyclin L1
CDC20 cell division cycle 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CGRRF1 cell growth regulator with ring finger domain 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
COCH cochlin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5R1 cytochrome b5 reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DLK1 delta-like 1 homolog (Drosophila)
EGR1 early growth response 1
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HIST1H4J histone cluster 1, H4j
HIST3H2A histone cluster 3, H2a
HOXD1 homeobox D1
IER5 immediate early response 5
IQCG IQ motif containing G
KIAA0907 KIAA0907
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MYBPC1 myosin binding protein C, slow type
NEK2 NIMA-related kinase 2
NEU1 sialidase 1 (lysosomal sialidase)
NPY neuropeptide Y
PHLDA2 pleckstrin homology-like domain, family A, member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
RAD9A RAD9 homolog A (S. pombe)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TESC tescalcin
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
ZFAND6 zinc finger, AN1-type domain 6

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP9A ATPase, class II, type 9A
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CCND2 cyclin D2
CD200 CD200 molecule
CERS6 ceramide synthase 6
COBLL1 cordon-bleu WH2 repeat protein-like 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DTX4 deltex 4, E3 ubiquitin ligase
EDNRB endothelin receptor type B
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IQGAP1 IQ motif containing GTPase activating protein 1
IRF8 interferon regulatory factor 8
ITGA6 integrin, alpha 6
KIF5B kinesin family member 5B
LOX lysyl oxidase
LRP4 low density lipoprotein receptor-related protein 4
MACF1 microtubule-actin crosslinking factor 1
MAGEA3 melanoma antigen family A3
MEIS1 Meis homeobox 1
MMP12 matrix metallopeptidase 12
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NEBL nebulette
NRCAM neuronal cell adhesion molecule
PDIA3 protein disulfide isomerase family A, member 3
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKP4 plakophilin 4
PLBD1 phospholipase B domain containing 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PSD3 pleckstrin and Sec7 domain containing 3
RBL2 retinoblastoma-like 2
RGS5 regulator of G-protein signaling 5
SCARB2 scavenger receptor class B, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SORBS2 sorbin and SH3 domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SVIL supervillin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TKT transketolase
TMEM47 transmembrane protein 47
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
VDAC1 voltage-dependent anion channel 1
WAC WW domain containing adaptor with coiled-coil
ZMYND11 zinc finger, MYND-type containing 11