BRD-K13662825_dinaciclib_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K13662825_dinaciclib_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ASPN asporin
ATF3 activating transcription factor 3
BST2 bone marrow stromal cell antigen 2
CCL5 chemokine (C-C motif) ligand 5
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
ECM1 extracellular matrix protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
FABP4 fatty acid binding protein 4, adipocyte
FAM162A family with sequence similarity 162, member A
FAM69A family with sequence similarity 69, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GAA glucosidase, alpha; acid
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
IFITM1 interferon induced transmembrane protein 1
IL7R interleukin 7 receptor
ISG15 ISG15 ubiquitin-like modifier
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
NREP neuronal regeneration related protein
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RRAGD Ras-related GTP binding D
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14A transmembrane protein 14A

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CDC25A cell division cycle 25A
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
FBL fibrillarin
GRWD1 glutamate-rich WD repeat containing 1
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IRS2 insulin receptor substrate 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MSH6 mutS homolog 6
MYO10 myosin X
NOP56 NOP56 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBL1X transducin (beta)-like 1X-linked
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TSPAN4 tetraspanin 4
TXLNA taxilin alpha
USP22 ubiquitin specific peptidase 22