BRD-K13646352_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K13646352_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTB actin, beta
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BTG2 BTG family, member 2
CD9 CD9 molecule
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLIC4 chloride intracellular channel 4
COL14A1 collagen, type XIV, alpha 1
CRIP2 cysteine-rich protein 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EVI2A ecotropic viral integration site 2A
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAR2 fatty acyl CoA reductase 2
GPM6B glycoprotein M6B
GRB10 growth factor receptor-bound protein 10
GSN gelsolin
H1F0 H1 histone family, member 0
HIST1H2AC histone cluster 1, H2ac
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGKV4-1 immunoglobulin kappa variable 4-1
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
JUND jun D proto-oncogene
KLF2 Kruppel-like factor 2
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHOB ras homolog family member B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRED2 sprouty-related, EVH1 domain containing 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THBS1 thrombospondin 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VIM vimentin
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
APOB apolipoprotein B
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COLEC12 collectin sub-family member 12
CXADR coxsackie virus and adenovirus receptor
DMD dystrophin
DTX4 deltex 4, E3 ubiquitin ligase
ERBB4 erb-b2 receptor tyrosine kinase 4
GOLGA8A golgin A8 family, member A
HEBP1 heme binding protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ITM2A integral membrane protein 2A
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LPCAT1 lysophosphatidylcholine acyltransferase 1
MCAM melanoma cell adhesion molecule
MRPS2 mitochondrial ribosomal protein S2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
P3H2 prolyl 3-hydroxylase 2
POSTN periostin, osteoblast specific factor
REG1A regenerating islet-derived 1 alpha
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNX10 sorting nexin 10
SYBU syntabulin (syntaxin-interacting)
WNT5A wingless-type MMTV integration site family, member 5A
ZW10 zw10 kinetochore protein