BRD-K13566078_BMS-345541_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K13566078_BMS-345541_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
AQP3 aquaporin 3 (Gill blood group)
AQP9 aquaporin 9
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BCHE butyrylcholinesterase
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C5AR1 complement component 5a receptor 1
CCND2 cyclin D2
CD46 CD46 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COMT catechol-O-methyltransferase
CSTA cystatin A (stefin A)
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
EGFL6 EGF-like-domain, multiple 6
FASTKD5 FAST kinase domains 5
FBN1 fibrillin 1
FGFR3 fibroblast growth factor receptor 3
FKBP1A FK506 binding protein 1A, 12kDa
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GYPC glycophorin C (Gerbich blood group)
HIST1H2BD histone cluster 1, H2bd
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1RAP interleukin 1 receptor accessory protein
IL1RN interleukin 1 receptor antagonist
IQCG IQ motif containing G
JAG1 jagged 1
KRT13 keratin 13, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS2 Meis homeobox 2
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
NCF2 neutrophil cytosolic factor 2
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NRIP3 nuclear receptor interacting protein 3
PGK1 phosphoglycerate kinase 1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRAME preferentially expressed antigen in melanoma
PSPH phosphoserine phosphatase
PTPRK protein tyrosine phosphatase, receptor type, K
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SATB1 SATB homeobox 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPRR1B small proline-rich protein 1B
SYNGR3 synaptogyrin 3
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TREM1 triggering receptor expressed on myeloid cells 1
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ALCAM activated leukocyte cell adhesion molecule
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP9A ATPase, class II, type 9A
AURKA aurora kinase A
BCL2 B-cell CLL/lymphoma 2
BRCA1 breast cancer 1, early onset
CBR3 carbonyl reductase 3
CCNB1 cyclin B1
CDV3 CDV3 homolog (mouse)
CEP350 centrosomal protein 350kDa
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
GATA3 GATA binding protein 3
GPATCH8 G patch domain containing 8
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KDM5B lysine (K)-specific demethylase 5B
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT19 keratin 19, type I
LTF lactotransferrin
LXN latexin
MAPT microtubule-associated protein tau
MED13 mediator complex subunit 13
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NLK nemo-like kinase
NNMT nicotinamide N-methyltransferase
NUP62 nucleoporin 62kDa
PCM1 pericentriolar material 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMP22 peripheral myelin protein 22
POU2AF1 POU class 2 associating factor 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RNMT RNA (guanine-7-) methyltransferase
RREB1 ras responsive element binding protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SH3BP4 SH3-domain binding protein 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TLK2 tousled-like kinase 2
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TOR1A torsin family 1, member A (torsin A)
TUBD1 tubulin, delta 1
VAV3 vav 3 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2