BRD-K13566078_BMS-345541_HS578T_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K13566078_BMS-345541_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
AIF1 allograft inflammatory factor 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
BID BH3 interacting domain death agonist
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFD complement factor D (adipsin)
CHN2 chimerin 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLC Charcot-Leyden crystal galectin
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST3 cystatin C
CYBB cytochrome b-245, beta polypeptide
CYBRD1 cytochrome b reductase 1
DEFA4 defensin, alpha 4, corticostatin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EGFL6 EGF-like-domain, multiple 6
EIF5A eukaryotic translation initiation factor 5A
EPHA4 EPH receptor A4
EREG epiregulin
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FNBP1 formin binding protein 1
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GREB1 growth regulation by estrogen in breast cancer 1
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI6 interferon, alpha-inducible protein 6
IGF1 insulin-like growth factor 1 (somatomedin C)
IL2RG interleukin 2 receptor, gamma
ISG15 ISG15 ubiquitin-like modifier
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF10 Kruppel-like factor 10
LCN2 lipocalin 2
LRRC17 leucine rich repeat containing 17
LST1 leukocyte specific transcript 1
LYZ lysozyme
MAOA monoamine oxidase A
MATN2 matrilin 2
MXRA5 matrix-remodelling associated 5
NEFH neurofilament, heavy polypeptide
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PLBD1 phospholipase B domain containing 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRD protein tyrosine phosphatase, receptor type, D
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC35F2 solute carrier family 35, member F2
SPARCL1 SPARC-like 1 (hevin)
SQRDL sulfide quinone reductase-like (yeast)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOM stomatin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
TMEM14B transmembrane protein 14B
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ARID5B AT rich interactive domain 5B (MRF1-like)
AXIN1 axin 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHN1 chimerin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FZD7 frizzled class receptor 7
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
RBM34 RNA binding motif protein 34
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SPHK1 sphingosine kinase 1
TCF4 transcription factor 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TOP2A topoisomerase (DNA) II alpha 170kDa
WEE1 WEE1 G2 checkpoint kinase