BRD-K13566078_BMS-345541_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K13566078_BMS-345541_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BHLHE40 basic helix-loop-helix family, member e40
C7 complement component 7
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPB1 carboxypeptidase B1 (tissue)
CRLF1 cytokine receptor-like factor 1
CTSH cathepsin H
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
FASTKD5 FAST kinase domains 5
FLRT3 fibronectin leucine rich transmembrane protein 3
GSTA1 glutathione S-transferase alpha 1
HAMP hepcidin antimicrobial peptide
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL1RAP interleukin 1 receptor accessory protein
IRX5 iroquois homeobox 5
LAPTM4B lysosomal protein transmembrane 4 beta
MYO1B myosin IB
NFIL3 nuclear factor, interleukin 3 regulated
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
OAT ornithine aminotransferase
OXCT1 3-oxoacid CoA transferase 1
PEG10 paternally expressed 10
PFN2 profilin 2
PGC progastricsin (pepsinogen C)
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
RGCC regulator of cell cycle
RSRC2 arginine/serine-rich coiled-coil 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOX4 SRY (sex determining region Y)-box 4
TFPI2 tissue factor pathway inhibitor 2
UGCG UDP-glucose ceramide glucosyltransferase
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AMIGO2 adhesion molecule with Ig-like domain 2
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCNF cyclin F
CD24 CD24 molecule
CD58 CD58 molecule
COL9A2 collagen, type IX, alpha 2
CRISP3 cysteine-rich secretory protein 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EGFR epidermal growth factor receptor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA3 EPH receptor A3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FZD7 frizzled class receptor 7
HMGA2 high mobility group AT-hook 2
ICAM1 intercellular adhesion molecule 1
IL1B interleukin 1, beta
KCTD5 potassium channel tetramerization domain containing 5
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LTBP1 latent transforming growth factor beta binding protein 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MXRA7 matrix-remodelling associated 7
NGRN neugrin, neurite outgrowth associated
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
PLAU plasminogen activator, urokinase
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCA protein kinase C, alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS4Y1 ribosomal protein S4, Y-linked 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STK10 serine/threonine kinase 10
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLR4 toll-like receptor 4
TNS3 tensin 3
TRAPPC3 trafficking protein particle complex 3
ZMIZ1 zinc finger, MIZ-type containing 1