BRD-K13390322_AT-7519_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K13390322_AT-7519_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
APOB apolipoprotein B
APOC2 apolipoprotein C-II
AQP9 aquaporin 9
BLNK B-cell linker
BPHL biphenyl hydrolase-like (serine hydrolase)
CD9 CD9 molecule
CFB complement factor B
CHN1 chimerin 1
CKAP4 cytoskeleton-associated protein 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CRELD2 cysteine-rich with EGF-like domains 2
DCN decorin
ERBB2 erb-b2 receptor tyrosine kinase 2
F12 coagulation factor XII (Hageman factor)
FABP1 fatty acid binding protein 1, liver
FBP1 fructose-1,6-bisphosphatase 1
GGCX gamma-glutamyl carboxylase
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
HIST1H1C histone cluster 1, H1c
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KNG1 kininogen 1
LOXL2 lysyl oxidase-like 2
MAB21L2 mab-21-like 2 (C. elegans)
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MME membrane metallo-endopeptidase
MX2 MX dynamin-like GTPase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RABAC1 Rab acceptor 1 (prenylated)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRPX sushi-repeat containing protein, X-linked
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TF transferrin
THBS2 thrombospondin 2
TSPAN8 tetraspanin 8
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UGP2 UDP-glucose pyrophosphorylase 2
UNC13B unc-13 homolog B (C. elegans)
VIM vimentin
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCL7B B-cell CLL/lymphoma 7B
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FASTKD5 FAST kinase domains 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
INHBB inhibin, beta B
KRT23 keratin 23, type I
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY1R neuropeptide Y receptor Y1
NUP62 nucleoporin 62kDa
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PLK2 polo-like kinase 2
RAE1 ribonucleic acid export 1
RNF139 ring finger protein 139
RNF6 ring finger protein (C3H2C3 type) 6
RPL27A ribosomal protein L27a
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPS11 ribosomal protein S11
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBPL1 TBP-like 1
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TOB2 transducer of ERBB2, 2
TXLNA taxilin alpha
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WIPF2 WAS/WASL interacting protein family, member 2
WT1 Wilms tumor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22