BRD-K13390322_AT-7519_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K13390322_AT-7519_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BHLHE40 basic helix-loop-helix family, member e40
BHMT2 betaine--homocysteine S-methyltransferase 2
BTG2 BTG family, member 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CCL21 chemokine (C-C motif) ligand 21
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CD38 CD38 molecule
CD48 CD48 molecule
CD96 CD96 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK6 cyclin-dependent kinase 6
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COPZ2 coatomer protein complex, subunit zeta 2
CPE carboxypeptidase E
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYR61 cysteine-rich, angiogenic inducer, 61
DACT1 dishevelled-binding antagonist of beta-catenin 1
DEFA4 defensin, alpha 4, corticostatin
DENND2D DENN/MADD domain containing 2D
DIO1 deiodinase, iodothyronine, type I
DLC1 DLC1 Rho GTPase activating protein
DMD dystrophin
DUSP14 dual specificity phosphatase 14
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FMO1 flavin containing monooxygenase 1
FMO2 flavin containing monooxygenase 2 (non-functional)
FOS FBJ murine osteosarcoma viral oncogene homolog
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LEF1 lymphoid enhancer-binding factor 1
LRRC17 leucine rich repeat containing 17
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL7A methyltransferase like 7A
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MPPED2 metallophosphoesterase domain containing 2
MSX1 msh homeobox 1
MT1E metallothionein 1E
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NID2 nidogen 2 (osteonidogen)
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
ORM1 orosomucoid 1
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG3 paternally expressed 3
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PSENEN presenilin enhancer gamma secretase subunit
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAGD Ras-related GTP binding D
SCG2 secretogranin II
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH2D1A SH2 domain containing 1A
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPARCL1 SPARC-like 1 (hevin)
SSBP2 single-stranded DNA binding protein 2
TICAM1 toll-like receptor adaptor molecule 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAV3 vav 3 guanine nucleotide exchange factor
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AXIN1 axin 1
BTG1 B-cell translocation gene 1, anti-proliferative
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPA3 carboxypeptidase A3 (mast cell)
CTBP2 C-terminal binding protein 2
DCK deoxycytidine kinase
EHF ets homologous factor
FERMT1 fermitin family member 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA1033 KIAA1033
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTERF3 mitochondrial transcription termination factor 3
OSBPL10 oxysterol binding protein-like 10
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PDHX pyruvate dehydrogenase complex, component X
PDS5A PDS5 cohesin associated factor A
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAP2A RAP2A, member of RAS oncogene family
RIN2 Ras and Rab interactor 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPRR1A small proline-rich protein 1A
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TXNDC9 thioredoxin domain containing 9
XPO1 exportin 1
YBX3 Y box binding protein 3