BRD-K13390322_AT-7519_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K13390322_AT-7519_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ANXA3 annexin A3
ANXA4 annexin A4
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APOD apolipoprotein D
ARL3 ADP-ribosylation factor-like 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BACE2 beta-site APP-cleaving enzyme 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCHE butyrylcholinesterase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CEP57 centrosomal protein 57kDa
CETN2 centrin, EF-hand protein, 2
CETN3 centrin, EF-hand protein, 3
CFB complement factor B
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CTTN cortactin
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
CYB5R1 cytochrome b5 reductase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FZD6 frizzled class receptor 6
GLG1 golgi glycoprotein 1
GPC4 glypican 4
GSN gelsolin
HDGFRP3 hepatoma-derived growth factor, related protein 3
HP haptoglobin
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISYNA1 inositol-3-phosphate synthase 1
JAG2 jagged 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
NPTX2 neuronal pentraxin II
NUPR1 nuclear protein, transcriptional regulator, 1
OAT ornithine aminotransferase
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PFKM phosphofructokinase, muscle
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PRDX2 peroxiredoxin 2
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAD51C RAD51 paralog C
RNF130 ring finger protein 130
SDC2 syndecan 2
SH3YL1 SH3 and SYLF domain containing 1
SKP1 S-phase kinase-associated protein 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TNNC1 troponin C type 1 (slow)
TPD52L1 tumor protein D52-like 1
TPGS2 tubulin polyglutamylase complex subunit 2
TPM2 tropomyosin 2 (beta)
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
AMOTL2 angiomotin like 2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARF6 ADP-ribosylation factor 6
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BASP1 brain abundant, membrane attached signal protein 1
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF106 chromosome 1 open reading frame 106
CAB39 calcium binding protein 39
CANT1 calcium activated nucleotidase 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ELL2 elongation factor, RNA polymerase II, 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FRMD4B FERM domain containing 4B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGNBP2 gametogenetin binding protein 2
GSPT2 G1 to S phase transition 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HILPDA hypoxia inducible lipid droplet-associated
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMM2 phosphomannomutase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIN2 Ras and Rab interactor 2
RND3 Rho family GTPase 3
RNF19B ring finger protein 19B
RNMT RNA (guanine-7-) methyltransferase
RRAGC Ras-related GTP binding C
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMD4A sterile alpha motif domain containing 4A
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SNAP25 synaptosomal-associated protein, 25kDa
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WBP5 WW domain binding protein 5
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZEB2 zinc finger E-box binding homeobox 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF22 zinc finger protein 22