BRD-K13390322_AT-7519_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K13390322_AT-7519_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALG8 ALG8, alpha-1,3-glucosyltransferase
CAST calpastatin
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CLNS1A chloride channel, nucleotide-sensitive, 1A
CSRP2 cysteine and glycine-rich protein 2
CTSS cathepsin S
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DSTN destrin (actin depolymerizing factor)
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESRP1 epithelial splicing regulatory protein 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXF1 forkhead box F1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCLC glutamate-cysteine ligase, catalytic subunit
GM2A GM2 ganglioside activator
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HOOK2 hook microtubule-tethering protein 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER3 immediate early response 3
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPXN leupaxin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MYO6 myosin VI
NAV3 neuron navigator 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
OLFM4 olfactomedin 4
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAB25 RAB25, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SCD5 stearoyl-CoA desaturase 5
SCPEP1 serine carboxypeptidase 1
SESN1 sestrin 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TSPO translocator protein (18kDa)
TUSC3 tumor suppressor candidate 3
VAMP3 vesicle-associated membrane protein 3
WIF1 WNT inhibitory factor 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADCY9 adenylate cyclase 9
AMIGO2 adhesion molecule with Ig-like domain 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ASS1 argininosuccinate synthase 1
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CLIC5 chloride intracellular channel 5
CLU clusterin
DCK deoxycytidine kinase
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EAPP E2F-associated phosphoprotein
ERBB2 erb-b2 receptor tyrosine kinase 2
FADS1 fatty acid desaturase 1
FGB fibrinogen beta chain
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
GAS1 growth arrest-specific 1
GLRX glutaredoxin (thioltransferase)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP6 insulin-like growth factor binding protein 6
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
IQGAP2 IQ motif containing GTPase activating protein 2
JCHAIN joining chain of multimeric IgA and IgM
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0391 KIAA0391
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
MMP2 matrix metallopeptidase 2
MRPL12 mitochondrial ribosomal protein L12
NDC80 NDC80 kinetochore complex component
NOV nephroblastoma overexpressed
NUP62 nucleoporin 62kDa
ORM1 orosomucoid 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLXNC1 plexin C1
PNP purine nucleoside phosphorylase
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RELN reelin
RGS13 regulator of G-protein signaling 13
RNASE4 ribonuclease, RNase A family, 4
RYR1 ryanodine receptor 1 (skeletal)
SCAND1 SCAN domain containing 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPTSSA serine palmitoyltransferase, small subunit A
SRP54 signal recognition particle 54kDa
STK10 serine/threonine kinase 10
TAGLN transgelin
TBP TATA box binding protein
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM97 transmembrane protein 97
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM24 tripartite motif containing 24
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
USP6NL USP6 N-terminal like
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2