BRD-K13390322_AT-7519_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-K13390322_AT-7519_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACTA2 actin, alpha 2, smooth muscle, aorta
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
AOC3 amine oxidase, copper containing 3
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOC2 apolipoprotein C-II
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BHMT2 betaine--homocysteine S-methyltransferase 2
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD59 CD59 molecule, complement regulatory protein
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFB complement factor B
CFD complement factor D (adipsin)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN8 claudin 8
CNN1 calponin 1, basic, smooth muscle
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CRYAB crystallin, alpha B
CSRP2 cysteine and glycine-rich protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DEFB1 defensin, beta 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DSP desmoplakin
DYNLT3 dynein, light chain, Tctex-type 3
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GFOD1 glucose-fructose oxidoreductase domain containing 1
GHR growth hormone receptor
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBEGF heparin-binding EGF-like growth factor
HEG1 heart development protein with EGF-like domains 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
JAM2 junctional adhesion molecule 2
KRT17 keratin 17, type I
LAMP2 lysosomal-associated membrane protein 2
LEF1 lymphoid enhancer-binding factor 1
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LPPR1 lipid phosphate phosphatase-related protein type 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGT1 magnesium transporter 1
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MPPED2 metallophosphoesterase domain containing 2
MT1E metallothionein 1E
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MXRA7 matrix-remodelling associated 7
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NMU neuromedin U
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OLFM4 olfactomedin 4
PDGFD platelet derived growth factor D
PENK proenkephalin
PERP PERP, TP53 apoptosis effector
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRDX2 peroxiredoxin 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RCAN2 regulator of calcineurin 2
REG1A regenerating islet-derived 1 alpha
RELN reelin
RRAGD Ras-related GTP binding D
SATB1 SATB homeobox 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNX10 sorting nexin 10
STC1 stanniocalcin 1
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TF transferrin
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM47 transmembrane protein 47
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
UGT8 UDP glycosyltransferase 8
VAT1 vesicle amine transport 1
WIF1 WNT inhibitory factor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASXL2 additional sex combs like transcriptional regulator 2
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CEMIP cell migration inducing protein, hyaluronan binding
CENPA centromere protein A
CTBP2 C-terminal binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
LOXL1 lysyl oxidase-like 1
LRP4 low density lipoprotein receptor-related protein 4
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MYO10 myosin X
NUP62 nucleoporin 62kDa
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAB15 RAB15, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
SOX4 SRY (sex determining region Y)-box 4
TACC2 transforming, acidic coiled-coil containing protein 2
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon