BRD-K13094524_PFI-1_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K13094524_PFI-1_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
ANGPT1 angiopoietin 1
ARSE arylsulfatase E (chondrodysplasia punctata 1)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BPHL biphenyl hydrolase-like (serine hydrolase)
CCDC85B coiled-coil domain containing 85B
CCDC92 coiled-coil domain containing 92
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CIRBP cold inducible RNA binding protein
COCH cochlin
CTGF connective tissue growth factor
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
FILIP1L filamin A interacting protein 1-like
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
GPX2 glutathione peroxidase 2
GRK5 G protein-coupled receptor kinase 5
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
INSM1 insulinoma-associated 1
JAM3 junctional adhesion molecule 3
KRT13 keratin 13, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MX1 MX dynamin-like GTPase 1
MYLK myosin light chain kinase
NDNF neuron-derived neurotrophic factor
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
OSR2 odd-skipped related transciption factor 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QPCT glutaminyl-peptide cyclotransferase
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SNN stannin
SPINK1 serine peptidase inhibitor, Kazal type 1
SSBP2 single-stranded DNA binding protein 2
SST somatostatin
TBX3 T-box 3
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPST2 tyrosylprotein sulfotransferase 2
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBQLN2 ubiquilin 2
WBP5 WW domain binding protein 5
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY7 adenylate cyclase 7
AK4 adenylate kinase 4
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AQP1 aquaporin 1 (Colton blood group)
C3 complement component 3
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
COPS7A COP9 signalosome subunit 7A
CSTA cystatin A (stefin A)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
ELF5 E74-like factor 5 (ets domain transcription factor)
ESR1 estrogen receptor 1
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPR171 G protein-coupled receptor 171
GSTA1 glutathione S-transferase alpha 1
HOMER3 homer scaffolding protein 3
ICAM3 intercellular adhesion molecule 3
IGFBP3 insulin-like growth factor binding protein 3
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
LMO4 LIM domain only 4
LPAR1 lysophosphatidic acid receptor 1
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
MEX3D mex-3 RNA binding family member D
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NMI N-myc (and STAT) interactor
NUP62 nucleoporin 62kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PEA15 phosphoprotein enriched in astrocytes 15
PIP prolactin-induced protein
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RAD23B RAD23 homolog B (S. cerevisiae)
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SDC4 syndecan 4
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC43A3 solute carrier family 43, member 3
SNAP25 synaptosomal-associated protein, 25kDa
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATS2L spermatogenesis associated, serine-rich 2-like
TACSTD2 tumor-associated calcium signal transducer 2
TES testin LIM domain protein
TFPI2 tissue factor pathway inhibitor 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
VAMP8 vesicle-associated membrane protein 8
VTCN1 V-set domain containing T cell activation inhibitor 1
ZHX2 zinc fingers and homeoboxes 2