BRD-K13094524_PFI-1_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K13094524_PFI-1_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA3 annexin A3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
CALCA calcitonin-related polypeptide alpha
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND2 cyclin D2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CKM creatine kinase, muscle
CLGN calmegin
CORO1A coronin, actin binding protein, 1A
CSRP2 cysteine and glycine-rich protein 2
DAAM1 dishevelled associated activator of morphogenesis 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHA3 EPH receptor A3
F3 coagulation factor III (thromboplastin, tissue factor)
FZD5 frizzled class receptor 5
G6PD glucose-6-phosphate dehydrogenase
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HTRA1 HtrA serine peptidase 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDM5D lysine (K)-specific demethylase 5D
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LHFP lipoma HMGIC fusion partner
LTBP1 latent transforming growth factor beta binding protein 1
MEST mesoderm specific transcript
METTL7A methyltransferase like 7A
MID1 midline 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MOXD1 monooxygenase, DBH-like 1
NEB nebulin
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
RPS4Y1 ribosomal protein S4, Y-linked 1
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TCL1A T-cell leukemia/lymphoma 1A
TFF1 trefoil factor 1
TMEM100 transmembrane protein 100
TNNC1 troponin C type 1 (slow)
TSPAN8 tetraspanin 8
TTN titin
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
WDTC1 WD and tetratricopeptide repeats 1
ZBTB18 zinc finger and BTB domain containing 18
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACTN1 actinin, alpha 1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AQP3 aquaporin 3 (Gill blood group)
BST2 bone marrow stromal cell antigen 2
CAPN2 calpain 2, (m/II) large subunit
CD59 CD59 molecule, complement regulatory protein
COL3A1 collagen, type III, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DRAM1 DNA-damage regulated autophagy modulator 1
EMP3 epithelial membrane protein 3
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GRWD1 glutamate-rich WD repeat containing 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB7 homeobox B7
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IFITM3 interferon induced transmembrane protein 3
JADE2 jade family PHD finger 2
KIAA0907 KIAA0907
KRT17 keratin 17, type I
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCAM melanoma cell adhesion molecule
MFAP2 microfibrillar-associated protein 2
MOK MOK protein kinase
MT1E metallothionein 1E
MXRA7 matrix-remodelling associated 7
N4BP2L2 NEDD4 binding protein 2-like 2
PKP4 plakophilin 4
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON3 paraoxonase 3
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PYCR1 pyrroline-5-carboxylate reductase 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS10 regulator of G-protein signaling 10
SCGB1D2 secretoglobin, family 1D, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS3 sorbin and SH3 domain containing 3
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
UBXN8 UBX domain protein 8
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2