BRD-K12994359_Valdecoxib_VCAP_24.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

39 genes differentially expressed following the BRD-K12994359_Valdecoxib_VCAP_24.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC4 chloride intracellular channel 4
DDIT4 DNA-damage-inducible transcript 4
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
F12 coagulation factor XII (Hageman factor)
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
FXYD3 FXYD domain containing ion transport regulator 3
GRB10 growth factor receptor-bound protein 10
GUSBP3 glucuronidase, beta pseudogene 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPAP2B phosphatidic acid phosphatase type 2B
RHOB ras homolog family member B
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
STX1A syntaxin 1A (brain)
SYT17 synaptotagmin XVII
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
XBP1 X-box binding protein 1

decreased expression

Symbol Name
BAZ1A bromodomain adjacent to zinc finger domain, 1A
DHCR24 24-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
FAS Fas cell surface death receptor
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
IFI16 interferon, gamma-inducible protein 16
INSIG1 insulin induced gene 1
KRT13 keratin 13, type I
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
WT1 Wilms tumor 1