BRD-K12994359_Valdecoxib_HT29_24.0_h_177.6_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

256 genes differentially expressed following the BRD-K12994359_Valdecoxib_HT29_24.0_h_177.6_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACOX2 acyl-CoA oxidase 2, branched chain
ADAM9 ADAM metallopeptidase domain 9
AHCYL2 adenosylhomocysteinase-like 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BLVRB biliverdin reductase B
BPGM 2,3-bisphosphoglycerate mutase
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C1QA complement component 1, q subcomponent, A chain
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCPG1 cell cycle progression 1
CD14 CD14 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKAP4 cytoskeleton-associated protein 4
CP ceruloplasmin (ferroxidase)
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
GAB2 GRB2-associated binding protein 2
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GRB10 growth factor receptor-bound protein 10
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBE inhibin, beta E
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC8D leucine rich repeat containing 8 family, member D
MARS methionyl-tRNA synthetase
MB myoglobin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MVP major vault protein
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDZK1IP1 PDZK1 interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLCE1 phospholipase C, epsilon 1
PLD3 phospholipase D family, member 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RNF187 ring finger protein 187
RPS4Y1 ribosomal protein S4, Y-linked 1
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC22A18 solute carrier family 22, member 18
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TBCB tubulin folding cofactor B
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ALCAM activated leukocyte cell adhesion molecule
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBFB core-binding factor, beta subunit
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXO1 exonuclease 1
EXOSC9 exosome component 9
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM111A family with sequence similarity 111, member A
FAM46A family with sequence similarity 46, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA2 GATA binding protein 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HACD2 3-hydroxyacyl-CoA dehydratase 2
HAT1 histone acetyltransferase 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
LDLR low density lipoprotein receptor
LEPROTL1 leptin receptor overlapping transcript-like 1
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MBNL1 muscleblind-like splicing regulator 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MELK maternal embryonic leucine zipper kinase
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
NUP93 nucleoporin 93kDa
OIP5 Opa interacting protein 5
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLN phospholamban
PLXNC1 plexin C1
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTMA prothymosin, alpha
QDPR quinoid dihydropteridine reductase
RGS2 regulator of G-protein signaling 2
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFPQ splicing factor proline/glutamine-rich
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TEX30 testis expressed 30
TFAM transcription factor A, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TJP2 tight junction protein 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCL vinculin
VRK1 vaccinia related kinase 1
ZWILCH zwilch kinetochore protein