BRD-K12867552_THM-I-94_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K12867552_THM-I-94_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALR calreticulin
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREM cAMP responsive element modulator
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EMP1 epithelial membrane protein 1
EZR ezrin
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GSTM3 glutathione S-transferase mu 3 (brain)
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
INSIG1 insulin induced gene 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MLF1 myeloid leukemia factor 1
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
NOSIP nitric oxide synthase interacting protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL3 oxysterol binding protein-like 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
RAD9A RAD9 homolog A (S. pombe)
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
SGK1 serum/glucocorticoid regulated kinase 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
SST somatostatin
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STX1A syntaxin 1A (brain)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
BASP1 brain abundant, membrane attached signal protein 1
C2CD5 C2 calcium-dependent domain containing 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK4 cyclin-dependent kinase 4
CKAP4 cytoskeleton-associated protein 4
CSK c-src tyrosine kinase
CTSL cathepsin L
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
FAM57A family with sequence similarity 57, member A
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GAS2 growth arrest-specific 2
GSPT2 G1 to S phase transition 2
HOXB7 homeobox B7
HOXC6 homeobox C6
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
ITGB5 integrin, beta 5
KIAA0368 KIAA0368
KIF20A kinesin family member 20A
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KPNB1 karyopherin (importin) beta 1
KRT15 keratin 15, type I
MGST2 microsomal glutathione S-transferase 2
MRPS2 mitochondrial ribosomal protein S2
MSMB microseminoprotein, beta-
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
NOV nephroblastoma overexpressed
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
OBSL1 obscurin-like 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARP TCR gamma alternate reading frame protein
TLK1 tousled-like kinase 1
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VDAC1 voltage-dependent anion channel 1
WARS tryptophanyl-tRNA synthetase
WDR43 WD repeat domain 43
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYM2 zinc finger, MYM-type 2