BRD-K12867552_THM-I-94_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K12867552_THM-I-94_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ALAS1 5'-aminolevulinate synthase 1
ANXA6 annexin A6
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BLVRA biliverdin reductase A
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CA2 carbonic anhydrase II
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDND1 claudin domain containing 1
CORO1A coronin, actin binding protein, 1A
CSRP1 cysteine and glycine-rich protein 1
CTSA cathepsin A
DCN decorin
DHCR7 7-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
ENAH enabled homolog (Drosophila)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FADS3 fatty acid desaturase 3
FAM50A family with sequence similarity 50, member A
FBP1 fructose-1,6-bisphosphatase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GLRX glutaredoxin (thioltransferase)
GOLGA7 golgin A7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRHPR glyoxylate reductase/hydroxypyruvate reductase
GRN granulin
GSN gelsolin
GUK1 guanylate kinase 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNGR1 interferon gamma receptor 1
IL32 interleukin 32
INSIG1 insulin induced gene 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
LGMN legumain
LPIN1 lipin 1
LTA4H leukotriene A4 hydrolase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
METRN meteorin, glial cell differentiation regulator
MGST3 microsomal glutathione S-transferase 3
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MXRA7 matrix-remodelling associated 7
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
OSBPL8 oxysterol binding protein-like 8
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PLA2G15 phospholipase A2, group XV
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RSRP1 arginine/serine-rich protein 1
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SRGN serglycin
SSR4 signal sequence receptor, delta
STK17A serine/threonine kinase 17a
TBPL1 TBP-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TPM2 tropomyosin 2 (beta)
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
WIPI1 WD repeat domain, phosphoinositide interacting 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS2 growth arrest-specific 2
GPX2 glutathione peroxidase 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KRT15 keratin 15, type I
KYNU kynureninase
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POSTN periostin, osteoblast specific factor
PTGES prostaglandin E synthase
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
ZHX2 zinc fingers and homeoboxes 2