BRD-K12867552_THM-I-94_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

306 genes differentially expressed following the BRD-K12867552_THM-I-94_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOA aldolase A, fructose-bisphosphate
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANO10 anoctamin 10
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATF3 activating transcription factor 3
ATOX1 antioxidant 1 copper chaperone
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BPGM 2,3-bisphosphoglycerate mutase
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCND3 cyclin D3
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CREG1 cellular repressor of E1A-stimulated genes 1
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CYBB cytochrome b-245, beta polypeptide
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FAM117A family with sequence similarity 117, member A
FAM131A family with sequence similarity 131, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRY furry homolog (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GM2A GM2 ganglioside activator
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HEPH hephaestin
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT27 intraflagellar transport 27
IGL immunoglobulin lambda locus
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
LGMN legumain
LIPG lipase, endothelial
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOB monoamine oxidase B
MGST3 microsomal glutathione S-transferase 3
MMP1 matrix metallopeptidase 1
NAGK N-acetylglucosamine kinase
NCALD neurocalcin delta
NCF2 neutrophil cytosolic factor 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEU1 sialidase 1 (lysosomal sialidase)
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPC surfactant protein C
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK17A serine/threonine kinase 17a
STX7 syntaxin 7
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
THEMIS2 thymocyte selection associated family member 2
TPP1 tripeptidyl peptidase I
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANO1 anoctamin 1, calcium activated chloride channel
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF5 activating transcription factor 5
AURKA aurora kinase A
AURKB aurora kinase B
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHRDL1 chordin-like 1
CLU clusterin
COCH cochlin
COL6A2 collagen, type VI, alpha 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DCTD dCMP deaminase
DEK DEK proto-oncogene
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
EHF ets homologous factor
EMP3 epithelial membrane protein 3
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM3 interferon induced transmembrane protein 3
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLK10 kallikrein-related peptidase 10
LMNB1 lamin B1
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LY6E lymphocyte antigen 6 complex, locus E
MALL mal, T-cell differentiation protein-like
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MBNL1 muscleblind-like splicing regulator 1
MDK midkine (neurite growth-promoting factor 2)
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MFAP5 microfibrillar associated protein 5
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MLPH melanophilin
MUC16 mucin 16, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXRA5 matrix-remodelling associated 5
MYO5C myosin VC
MYOF myoferlin
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NMI N-myc (and STAT) interactor
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFC platelet derived growth factor C
PDLIM4 PDZ and LIM domain 4
PGM1 phosphoglucomutase 1
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRC1 protein regulator of cytokinesis 1
PRDX3 peroxiredoxin 3
PRMT1 protein arginine methyltransferase 1
PRNP prion protein
PTMA prothymosin, alpha
RAD51 RAD51 recombinase
RANGRF RAN guanine nucleotide release factor
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
SCRN1 secernin 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SF3B3 splicing factor 3b, subunit 3, 130kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35F2 solute carrier family 35, member F2
SLC43A3 solute carrier family 43, member 3
SMC2 structural maintenance of chromosomes 2
SMC4 structural maintenance of chromosomes 4
SORBS3 sorbin and SH3 domain containing 3
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREK1 splicing regulatory glutamine/lysine-rich protein 1
STAG1 stromal antigen 1
STAG2 stromal antigen 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUMO3 small ubiquitin-like modifier 3
SYBU syntabulin (syntaxin-interacting)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMF1 TATA element modulatory factor 1
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1A torsin family 1, member A (torsin A)
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN6 tetraspanin 6
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VBP1 von Hippel-Lindau binding protein 1
WFDC2 WAP four-disulfide core domain 2
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YBX3 Y box binding protein 3
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF532 zinc finger protein 532