BRD-K12867552_THM-I-94_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

382 genes differentially expressed following the BRD-K12867552_THM-I-94_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADA adenosine deaminase
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANO10 anoctamin 10
ARHGAP29 Rho GTPase activating protein 29
ASMTL acetylserotonin O-methyltransferase-like
ATF3 activating transcription factor 3
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C18ORF8 chromosome 18 open reading frame 8
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC28A coiled-coil domain containing 28A
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CETN2 centrin, EF-hand protein, 2
CPM carboxypeptidase M
CPVL carboxypeptidase, vitellogenic-like
CRIP2 cysteine-rich protein 2
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EMX2 empty spiracles homeobox 2
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FADS3 fatty acid desaturase 3
FAM107A family with sequence similarity 107, member A
FAM117A family with sequence similarity 117, member A
FGF9 fibroblast growth factor 9
FGFR4 fibroblast growth factor receptor 4
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
G6PD glucose-6-phosphate dehydrogenase
GAS6 growth arrest-specific 6
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR137B G protein-coupled receptor 137B
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT27 intraflagellar transport 27
IFT57 intraflagellar transport 57
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
KIAA0226 KIAA0226
KIAA0513 KIAA0513
LAMP1 lysosomal-associated membrane protein 1
LGMN legumain
LIPA lipase A, lysosomal acid, cholesterol esterase
MAGEH1 melanoma antigen family H1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MICB MHC class I polypeptide-related sequence B
MLF1 myeloid leukemia factor 1
MYLIP myosin regulatory light chain interacting protein
NAGK N-acetylglucosamine kinase
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
OSTM1 osteopetrosis associated transmembrane protein 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDCD6 programmed cell death 6
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PLA2G15 phospholipase A2, group XV
PLD3 phospholipase D family, member 3
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRAF2 PRA1 domain family, member 2
PRUNE2 prune homolog 2 (Drosophila)
PSAP prosaposin
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB29 RAB29, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SEPHS2 selenophosphate synthetase 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNN stannin
SNX2 sorting nexin 2
SP110 SP110 nuclear body protein
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTSSA serine palmitoyltransferase, small subunit A
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TMEM50B transmembrane protein 50B
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YPEL5 yippee-like 5 (Drosophila)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADORA2B adenosine A2b receptor
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA1 annexin A1
ANXA3 annexin A3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CERS2 ceramide synthase 2
CFB complement factor B
CFH complement factor H
CKS1B CDC28 protein kinase regulatory subunit 1B
COCH cochlin
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST1 cystatin SN
CTBP1 C-terminal binding protein 1
CTPS2 CTP synthase 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
DCK deoxycytidine kinase
DCTD dCMP deaminase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DEK DEK proto-oncogene
DEPDC1 DEP domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECT2 epithelial cell transforming 2
EIF5 eukaryotic translation initiation factor 5
EPN2 epsin 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXOSC8 exosome component 8
F3 coagulation factor III (thromboplastin, tissue factor)
FAM129A family with sequence similarity 129, member A
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FANCI Fanconi anemia, complementation group I
FGB fibrinogen beta chain
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
FSTL1 follistatin-like 1
FXYD5 FXYD domain containing ion transport regulator 5
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPSM2 G-protein signaling modulator 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTF3A general transcription factor IIIA
GTSE1 G-2 and S-phase expressed 1
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNMT histamine N-methyltransferase
HOXB2 homeobox B2
HP haptoglobin
HSPA8 heat shock 70kDa protein 8
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL7R interleukin 7 receptor
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KLK11 kallikrein-related peptidase 11
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LAMA4 laminin, alpha 4
LMNB1 lamin B1
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK13 mitogen-activated protein kinase 13
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM7 minichromosome maintenance complex component 7
MDFIC MyoD family inhibitor domain containing
MGST2 microsomal glutathione S-transferase 2
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MSLN mesothelin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PDGFC platelet derived growth factor C
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRC1 protein regulator of cytokinesis 1
PRDX4 peroxiredoxin 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTMA prothymosin, alpha
PTPRC protein tyrosine phosphatase, receptor type, C
PTX3 pentraxin 3, long
RAD51 RAD51 recombinase
RBMX RNA binding motif protein, X-linked
RCN1 reticulocalbin 1, EF-hand calcium binding domain
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SHCBP1 SHC SH2-domain binding protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMC4 structural maintenance of chromosomes 4
SORBS2 sorbin and SH3 domain containing 2
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
STAG2 stromal antigen 2
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYBU syntabulin (syntaxin-interacting)
TACC3 transforming, acidic coiled-coil containing protein 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UCK2 uridine-cytidine kinase 2
UGDH UDP-glucose 6-dehydrogenase
USP22 ubiquitin specific peptidase 22
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3
ZNF532 zinc finger protein 532
ZWINT ZW10 interacting kinetochore protein